Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Trends Cell Biol. 2019 Oct;29(10):767-769. doi: 10.1016/j.tcb.2019.08.001. Epub 2019 Aug 27.
Xenophagy, the process of eliminating intracellular pathogens through the autophagy machinery, is an important defense mechanism against infectious disease, yet the underlying molecular mechanisms remain incompletely understood. Recent work (Xu et al., Cell, 2019) used the discovery of an inhibitor of xenophagy, SopF, to identify a SopF-sensitive mechanism that allows mammalian cells to detect invading bacteria.
异噬作用，即通过自噬机制清除细胞内病原体的过程，是一种重要的抗感染防御机制，但其中的分子机制仍不完全清楚。最近的研究（Xu 等人，《细胞》，2019）利用异噬作用抑制剂 SopF 的发现，鉴定了一种 SopF 敏感机制，使哺乳动物细胞能够检测到入侵的细菌。
