Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Neurosurg Clin N Am. 2019 Oct;30(4):473-482. doi: 10.1016/j.nec.2019.05.006. Epub 2019 Aug 7.
Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.
垂体腺瘤通常是生长缓慢的良性肿瘤。然而，50%至 60%的肿瘤在次全切除后会进展，30%的肿瘤在明显完全切除后会复发。治疗复发性垂体腺瘤的选择包括再次手术切除、放射治疗和全身治疗。对于复发性垂体腺瘤的管理，尚无共识方法。本文回顾了复发性腺瘤的自然史和预测临床行为的新兴生物标志物，以及这些具有挑战性的肿瘤各种治疗方法的结果，重点是手术治疗。
