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Recurrence rates of cutaneous squamous cell carcinoma of the head and neck after Mohs micrographic surgery vs. standard excision: a retrospective cohort study.Mohs 显微描记手术与标准切除术治疗头颈部皮肤鳞状细胞癌的复发率:一项回顾性队列研究。
Br J Dermatol. 2019 Aug;181(2):338-343. doi: 10.1111/bjd.17188. Epub 2018 Oct 28.
2
Updates on the Management of Non-Melanoma Skin Cancer (NMSC).非黑色素瘤皮肤癌(NMSC)管理的最新进展。
Healthcare (Basel). 2017 Nov 1;5(4):82. doi: 10.3390/healthcare5040082.
3
Clinical and Incidental Perineural Invasion of Cutaneous Squamous Cell Carcinoma: A Systematic Review and Pooled Analysis of Outcomes Data.皮肤鳞状细胞癌的临床及偶然神经周围浸润:结局数据的系统评价与汇总分析
JAMA Dermatol. 2017 Aug 1;153(8):781-788. doi: 10.1001/jamadermatol.2017.1680.
4
Ultraviolet Radiation Exposure and Its Impact on Skin Cancer Risk.紫外线辐射暴露及其对皮肤癌风险的影响。
Semin Oncol Nurs. 2016 Aug;32(3):241-54. doi: 10.1016/j.soncn.2016.05.005. Epub 2016 Jul 29.
5
Skin Malignancies of the Ear.耳部皮肤恶性肿瘤
Plast Reconstr Surg Glob Open. 2016 Feb 5;4(1):e604. doi: 10.1097/GOX.0000000000000585. eCollection 2016 Jan.
6
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.皮肤鳞状细胞癌复发、转移及疾病特异性死亡的危险因素:一项系统评价和Meta分析
JAMA Dermatol. 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994.
7
Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study.决定皮肤鳞状细胞癌预后的危险因素分析:一项前瞻性研究。
Lancet Oncol. 2008 Aug;9(8):713-20. doi: 10.1016/S1470-2045(08)70178-5. Epub 2008 Jul 9.
8
UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer.恶性黑色素瘤和非黑色素瘤皮肤癌中的紫外线损伤与DNA修复
Adv Exp Med Biol. 2008;624:162-78. doi: 10.1007/978-0-387-77574-6_13.
9
High-risk cutaneous squamous cell carcinoma of the head and neck.头颈部高危皮肤鳞状细胞癌
J Biomed Biotechnol. 2007;2007(3):80572. doi: 10.1155/2007/80572. Epub 2007 Apr 3.
10
Mohs micrographic surgery: established uses and emerging trends.莫氏显微外科手术:既定用途与新趋势
Oncology (Williston Park). 2005 Aug;19(9):1165-71; discussion 1171-2, 1175.

高危鳞状细胞癌及其对一名62岁男性外科医生的影响。

High-risk squamous cell carcinoma and its impact on a 62-year-old male surgeon.

作者信息

Jubran Jubran, Sengelmann Roberta D

机构信息

Santa Barbara Skin Institute, Santa Barbara, California, USA.

Dermatology, Irvine School of Medicine, University of California, Irvine, California, USA.

出版信息

BMJ Case Rep. 2019 Aug 30;12(8):e229940. doi: 10.1136/bcr-2019-229940.

DOI:10.1136/bcr-2019-229940
PMID:31471358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6720856/
Abstract

Cutaneous squamous cell carcinoma (cSCC) is a form of non-melanoma skin cancer responsible for more deaths in the USA than all other skin cancers combined. Some features, including anatomic site, are considered high risk in nature and pose a challenge for complete tumour removal. We present a case of a 62-year-old male surgeon with a multiply recurrent cSCC of the right conchal bowl. The tumour described herein was doubly recurrent to excision with a standard margin and could ultimately not be cleared with Mohs micrographic surgery. Ultimately, it necessitated auriculectomy and parotidectomy. This case exemplifies the pitfalls of traditional wide local excision with standard pathologic processing for high-risk cSCC.

摘要

皮肤鳞状细胞癌(cSCC)是一种非黑色素瘤皮肤癌,在美国导致的死亡人数超过其他所有皮肤癌的总和。包括解剖部位在内的一些特征本质上被认为是高风险的,给完整切除肿瘤带来了挑战。我们报告一例62岁男性外科医生,患有右耳甲腔多发性复发性cSCC。本文所述肿瘤经标准切缘切除后复发两次,最终无法通过莫氏显微外科手术清除。最终,需要进行耳廓切除术和腮腺切除术。该病例例证了对高风险cSCC采用传统广泛局部切除加标准病理处理的缺陷。