Kalfarentzos F, Spiliotis J, Christopoulos D, Theoharis D, Kalpaxis D, Williams M, Androulakis J
Department of Surgery, University of Patras, Greece.
Eur Surg Res. 1988;20(5-6):352-7. doi: 10.1159/000128785.
The possibility of intraperitoneal (IP) parenteral nutrition was suggested after the observation that glucose and amino acids pass from the peritoneal cavity into the systemic circulation. We used rabbits to study the characteristics of the transfer of glucose, lipids and amino acids. An IP injection of glucose 25% (1 g/kg) produced a peak level in the serum within 40 min. A 20% fat solution (1 g/kg) showed maximum serum levels of triglycerides and total lipid in 2.5 h, while a standard amino acid solution (1.5 g/kg) enriched with 25 14C-phenylalanine peaked serum levels in 16 min. The 4 rabbits survived for 28 days with IP glucose, amino acids and lipids as the only form of nutrition, apart from water. When sacrificed after 28 days histology of peritoneum, liver, spleen, gut and kidney showed no abnormality. We conclude that the basic nutritional components are adequately absorbed through the peritoneum, and that long-term nutritional support can be achieved uneventfully with IP administration of nutritional solutions.
观察到葡萄糖和氨基酸可从腹腔进入体循环后，有人提出了腹腔内（IP）胃肠外营养的可能性。我们用兔子来研究葡萄糖、脂质和氨基酸的转运特性。腹腔注射25%的葡萄糖（1 g/kg）在40分钟内使血清中达到峰值水平。20%的脂肪溶液（1 g/kg）在2.5小时内使血清甘油三酯和总脂质达到最高水平，而富含25 14C-苯丙氨酸的标准氨基酸溶液（1.5 g/kg）在16分钟内使血清水平达到峰值。4只兔子以腹腔内葡萄糖、氨基酸和脂质作为唯一的营养形式（除水外）存活了28天。28天后处死时，腹膜、肝脏、脾脏、肠道和肾脏的组织学检查未显示异常。我们得出结论，基本营养成分可通过腹膜充分吸收，并且通过腹腔内给予营养溶液可以顺利实现长期营养支持。
