Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Department of Dermatology, 6MDG, MacDill Air Force Base, Florida, USA.
Br J Clin Pharmacol. 2019 Dec;85(12):2694-2706. doi: 10.1111/bcp.14112. Epub 2019 Nov 5.
Vaccination continues to be the single most important and successful public health intervention, due to its prevention of morbidity and mortality from prevalent infectious diseases. Severe immunologically mediated reactions are rare and less common with the vaccine than the true infection. However, these events can cause public fearfulness and loss of confidence in the safety of vaccination. In this paper, we perform a systematic literature search and narrative review of immune-mediated vaccine adverse events and their known and proposed mechanisms, and outline directions for future research. Improving our knowledge base of severe immunologically mediated vaccine reactions and their management drives better vaccine safety and efficacy outcomes.
疫苗接种仍然是最重要和最成功的公共卫生干预措施之一，因为它可以预防流行传染病的发病率和死亡率。严重的免疫介导反应很少见，而且比真正的感染更不常见。然而，这些事件会引起公众的恐惧和对疫苗安全性的信心丧失。在本文中，我们对免疫介导的疫苗不良反应及其已知和提出的机制进行了系统的文献检索和叙述性综述，并概述了未来研究的方向。提高我们对严重免疫介导疫苗反应及其管理的知识基础，有助于提高疫苗的安全性和效果。
