微粒体与认知和功能状态有关，从正常衰老到痴呆。
Microparticles are related to cognitive and functional status from normal aging to dementia.
机构信息
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
J Neuroimmunol. 2019 Nov 15;336:577027. doi: 10.1016/j.jneuroim.2019.577027. Epub 2019 Aug 21.
Recently, we have shown that microparticles (MPs) levels derived from leukocytes (LMPs), endothelium (EMPs), neurons (NMPs) and those expressing tissue factor (TFMPs) were higher in Alzheimer's Disease (AD) patients when compared to cognitively healthy subjects. Therefore, in this study we proposed to investigate the correlation between MPs levels, cognitive performance and functional status in a sample of elderly individuals. We evaluated MPs derived from platelets (PMPs), LMPs, EMPs, NMPs and TFMPs in 43 participants, of whom 12 with probable dementia due to AD, 16 with mild cognitive impairment (MCI) and 15 with no objective cognitive or functional impairment. PMPs, LMPs and TFMPs, were associated with cognitive impairment in this population. LMPs and NMP, were associated to lower functional performance in the elderly sample. These results suggest that MPs may be involved in the pathophysiology of neurodegenerative disorders.
最近，我们已经表明，与认知健康的受试者相比，阿尔茨海默病（AD）患者的白细胞（LMPs）、内皮细胞（EMPs）、神经元（NMPs）和表达组织因子（TFMPs）的微粒（MPs）水平更高。因此，在这项研究中，我们提出在老年人群体中研究 MPs 水平、认知表现和功能状态之间的相关性。我们评估了来自血小板（PMPs）、LMPs、EMPs、NMPs 和 TFMPs 的 MPs，参与者共 43 名，其中 12 名患有 AD 引起的可能痴呆，16 名患有轻度认知障碍（MCI），15 名无客观认知或功能障碍。在该人群中，PMPs、LMPs 和 TFMPs 与认知障碍相关。LMPs 和 NMP 与老年人样本的较低功能表现相关。这些结果表明 MPs 可能参与神经退行性疾病的病理生理学。
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