微粒：多囊卵巢综合征中的炎症和止血生物标志物
Microparticles: Inflammatory and haemostatic biomarkers in Polycystic Ovary Syndrome.
作者信息
Carvalho L M L, Ferreira C N, Sóter M O, Sales M F, Rodrigues K F, Martins S R, Candido A L, Reis F M, Silva I F O, Campos F M F, Gomes K B
机构信息
Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Colégio Técnico, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
Mol Cell Endocrinol. 2017 Mar 5;443:155-162. doi: 10.1016/j.mce.2017.01.017. Epub 2017 Jan 11.
Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p < 0.05). TFMPs was similar between the groups (p = 0.379). In conclusion, these MPs populations could be useful biomarkers for association with thrombosis and cardiovascular disease in PCOS women.
多囊卵巢综合征（PCOS）与慢性低度炎症以及易于发生止血和动脉粥样硬化并发症相关。这项病例对照研究评估了PCOS患者的微粒（MPs）特征，并将这些MPs与临床和生化参数相关联。通过流式细胞术评估了源自血小板的微粒（PMPs）、白细胞的微粒（LMPs）和内皮细胞的微粒（EMPs），以及表达组织因子的微粒（TFMPs），比较了PCOS女性（n = 50）和健康对照组（n = 50）。与对照组相比，PCOS女性的总MPs、PMPs、LMPs和EMPs水平升高（所有p < 0.05）。两组之间的TFMPs相似（p = 0.379）。总之，这些MPs群体可能是与PCOS女性血栓形成和心血管疾病相关的有用生物标志物。
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