Lee Tiffany C, Morris Mackenzie C, Patel Sameer H, Shah Shimul A
Cincinnati Research on Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267-0558, USA.
Cincinnati Research on Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267-0558, USA.
Surg Oncol Clin N Am. 2019 Oct;28(4):763-782. doi: 10.1016/j.soc.2019.06.010. Epub 2019 Aug 2.
Surgical management of primary liver and biliary tract tumors has evolved over the past several decades, resulting in improved outcomes in these malignancies with historically poor prognoses. Expansion of patient selection criteria, progress in neoadjuvant and adjuvant therapies, development of techniques to increase future liver remnant, and the select utilization of liver transplantation have all contributed to increasing the patient pool for surgical intervention. Ongoing and future studies need to focus on improving multimodality treatment regimens and further refining the selection criteria for transplantation in order to optimize utilization of limited organ resources.
在过去几十年中，原发性肝脏和胆道肿瘤的外科治疗不断发展，使得这些既往预后较差的恶性肿瘤的治疗效果得到改善。患者选择标准的扩大、新辅助和辅助治疗的进展、增加未来肝残余量技术的发展以及肝移植的选择性应用，都有助于扩大手术干预的患者群体。正在进行的和未来的研究需要专注于改进多模式治疗方案，并进一步完善移植选择标准，以优化有限器官资源的利用。
