Hieu Ho Trung, Ha Nguyen Thu, Song Le Huu, Nghi Tran Hong
Department of Nephrology and Transplantation, 108 Military Central Hospital, Hanoi, Vietnam.
Department of Nutrition, 108 Military Central Hospital, Hanoi, Vietnam.
Transplant Proc. 2019 Oct;51(8):2549-2554. doi: 10.1016/j.transproceed.2019.03.067. Epub 2019 Aug 28.
The prevalence of chronic kidney failure is significantly increasing in Vietnam, causing a burden for health care. This study assessed the relationship of HLA-A, -B, and -DRB1 alleles with end-stage renal disease (ESRD).
A retrospective, cross-sectional study and a comparative study using secondary data analysis were conducted on 196 ESRD patients and 187 controls from 2009 to 2017. The patient and donor profiles were collected from medical records, including age, sex, etiology of renal failure, and HLA phenotypes. HLA-A*, -B*, and -DRB1* typing were done by polymerase chain reaction-sequence specific primers.
The most frequent HLA alleles in Vietnamese patients with ESRD were HLA-A02, -A11, -B15, -B46, -DRB104, -DRB109, and -DRB112. The haplotypes HLA-A0233 (odds ratio [OR] = 0.40, 95% CI: 0.15-0.98) had a negative association for ESRD. The haplotypes HLA-B1515 (OR = 4.14, 95% CI: 1.52-11.26) and HLA-DRB11212 (OR = 2.01, 95% CI: 1.06-3.81) had a positive association for ESRD. The haplotypes HLA-B1515 (OR = 4.69, 95% CI: 1.69-13.03) and -DRB11212 (OR = 2.15, 95% CI: 1.10-4.21) had a positive association for ESRD related to glomerulonephritis. The HLA-B*1557 (OR = 17.34, 95% CI: 2.70-11.49) had a positive association for ESRD related to hypertension.
The haplotypes of HLA class I and II had significant relationships with ESRD. The results of our study should be confirmed in further investigations.
越南慢性肾衰竭的患病率正在显著上升，给医疗保健带来了负担。本研究评估了HLA - A、- B和 - DRB1等位基因与终末期肾病（ESRD）之间的关系。
采用回顾性横断面研究和二次数据分析的比较研究，对2009年至2017年的196例ESRD患者和187例对照进行研究。从病历中收集患者和供体的资料，包括年龄、性别、肾衰竭病因和HLA表型。通过聚合酶链反应 - 序列特异性引物进行HLA - A*、- B和 - DRB1分型。
越南ESRD患者中最常见的HLA等位基因是HLA - A02、- A11、- B15、- B46、- DRB104、- DRB109和 - DRB112。单倍型HLA - A0233（优势比[OR]=0.40，95%可信区间：0.15 - 0.98）与ESRD呈负相关。单倍型HLA - B1515（OR = 4.14，95%可信区间：1.52 - 11.26）和HLA - DRB11212（OR = 2.01，95%可信区间：1.06 - 3.81）与ESRD呈正相关。单倍型HLA - B1515（OR = 4.69，95%可信区间：1.69 - 13.03）和 - DRB11212（OR = 2.15，95%可信区间：1.10 - 4.21）与肾小球肾炎相关的ESRD呈正相关。HLA - B*1557（OR = 17.34，95%可信区间：2.70 - 11.49）与高血压相关的ESRD呈正相关。
HLAⅠ类和Ⅱ类单倍型与ESRD有显著关系。我们研究的结果应在进一步调查中得到证实。
