核仁作为一种蛋白稳态调节剂。

The Nucleolus as a Proteostasis Regulator.

机构信息

Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

出版信息

Trends Cell Biol. 2019 Nov;29(11):849-851. doi: 10.1016/j.tcb.2019.08.002. Epub 2019 Aug 28.

DOI:10.1016/j.tcb.2019.08.002

PMID:31473054

Abstract

Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.

摘要

蛋白质错误折叠与疾病有关，那么哺乳动物细胞如何应对核内错误折叠蛋白质的负担呢？最近发表在《科学》杂志上的一项研究（Frottin 等人，2019 年）表明，在蛋白毒性应激下，核仁可以储存一些错误折叠的蛋白质进行重折叠或降解。