Kostko S Z
Kardiologiia. 1988 Oct;28(10):85-8.
In acute experiments with 20 isolated cat hearts, corinfar (0.1, 1, and 10 micrograms) and nitroglycerin (1, 10, and 100 micrograms) and their combination were tested for their effects on cardiac vessels and performance. Corinfar and nitroglycerin were found to exert a dose-dependent coronary dilating effect; however, more pronounced and prolonged action was shown by corinfar. The combination of the drugs produced more rapid and prolonged decrease in coronary artery tone when they were given alone. Nitroglycerin failed to affect venous return from the coronary bed and cardiac function, whereas corinfar increased venous return in most cases and decreased it in some cases, exhibited negative ino- and chronotropic effects, and reduced myocardial oxygen consumption.
在对20个离体猫心脏进行的急性实验中，测试了科立泛（0.1、1和10微克）、硝酸甘油（1、10和100微克）及其组合对心脏血管和功能的影响。发现科立泛和硝酸甘油均具有剂量依赖性的冠状动脉舒张作用；然而，科立泛的作用更显著且持续时间更长。单独给药时，药物组合使冠状动脉张力下降更快且更持久。硝酸甘油未影响冠状动脉床的静脉回流和心脏功能，而科立泛在大多数情况下增加静脉回流，在某些情况下减少静脉回流，表现出负性变力和变时作用，并降低心肌耗氧量。
