Aksakal Gamze, Ng Suat, An Vinna
Department of Surgery, Eastern Health, Box Hill, Victoria, Australia.
Department of Surgery, St Vincents Hospital, Melbourne, Victoria, Australia.
BMJ Case Rep. 2019 Aug 30;12(8):e229961. doi: 10.1136/bcr-2019-229961.
A 63-year-old man with a history of gastro-oesophageal reflux disease underwent defunctioning loop ileostomy for obstructing metastatic rectal cancer prior to receiving long-course neoadjuvant chemoradiotherapy. Four months post completion of neoadjuvant therapy, he underwent an uncomplicated elective ultra-low anterior resection with formation of colonic J pouch and first stage liver metastasectomy for bilobar liver disease. At 1 year, he proceeded to an elective closure of loop ileostomy. Unfortunately, his postoperative course was complicated by profuse diarrhoea with subsequent colonic perforation, necessitating an emergency laparotomy and ileocolic resection with end ileostomy formation. Histopathology and stool studies were consistent with Typhi infection. At the present time, Typhi causing toxic megacolon and subsequent colonic perforation is an uncommon phenomenon in Australia. Here, we present an unusual case and explain why bowel perforation in this instance likely had a multifactorial aetiology.
一名63岁男性,有胃食管反流病病史,在接受长疗程新辅助放化疗前,因转移性直肠癌梗阻行转流性回肠造口术。新辅助治疗结束4个月后,他接受了一次顺利的选择性超低位前切除术,同时形成结肠J袋,并因双侧肝脏疾病进行了一期肝转移瘤切除术。1年后,他接受了选择性回肠造口关闭术。不幸的是,他术后出现大量腹泻并继发结肠穿孔,需要进行急诊剖腹手术和回结肠切除术并形成末端回肠造口。组织病理学和粪便检查结果与伤寒感染相符。目前,在澳大利亚,伤寒导致中毒性巨结肠及随后的结肠穿孔是一种罕见现象。在此,我们报告一例罕见病例,并解释为何该例肠道穿孔可能具有多因素病因。