动脉瘤结构：首例血管外光学相干断层成像术对人脑动脉瘤的活体成像。
Aneurysm Architecture: First in vivo Imaging of Human Cerebral Aneurysms with Extravascular Optical Coherence Tomography.
机构信息
Department of Neurosurgery, KRH Klinikum Nordstadt, Hannover, Germany,
Department of Neurosurgery, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany,
出版信息
Cerebrovasc Dis. 2019;48(1-2):26-31. doi: 10.1159/000502450. Epub 2019 Aug 30.
OBJECTIVE
The present study was conducted to explore the value of 3-dimensional microscope integrated extravascular optical coherence tomography (OCT) as the first suitable intraoperative imaging modality of cerebral aneurysm (CA) and parent vessel wall morphology.
METHODS
Incidental CAs (n = 16) of the anterior circulation with indication for microsurgical clipping were scanned.
RESULTS
Analysis revealed that intraoperative OCT achieved to delineate the microstructural composition of the parent vessel in all cases and the CA wall in 68.8%. Clinical relevant characteristics such as thickness, calcification, residual tunica media, and atherosclerotic plaque of CA wall could be demonstrated with high image quality approaching the spatial resolution of histopathology.
CONCLUSION
Our findings demonstrate that intraoperative OCT may hold promise as an additional imaging tool during neurovascular procedures.
目的
本研究旨在探讨三维显微镜整合血管外光相干断层扫描（OCT）作为脑动脉瘤（CA）和载瘤动脉壁形态学的首选术中成像方式的价值。
方法
对有显微夹闭指征的前循环偶然发现的 CA（n = 16）进行扫描。
结果
分析显示，术中 OCT 成功地在所有病例中描绘了载瘤动脉的微观结构组成，在 68.8%的病例中描绘了 CA 壁的微观结构组成。可以用高图像质量显示与组织病理学的空间分辨率接近的与临床相关的特征，如 CA 壁的厚度、钙化、残余中膜和动脉粥样硬化斑块。
结论
我们的研究结果表明，术中 OCT 可能作为一种额外的神经血管手术中的成像工具具有应用前景。
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