Vesterhauge S, Peitersen E
Adv Otorhinolaryngol. 1979;25:173-7. doi: 10.1159/000402938.
A striking difference between the two anticholinergic drugs was observed. Atropine only modified the eye speed of the slow phase (mes), whereas scopolamine modified both parameters measured, mes and duration. Amphetamine and caffeine prolonged the duration, leaving the mes unchanged. All antiemetic drugs inhibited both parameters. It is concluded that the effect of a drug on the caloric reaction gives insufficient information in the preclinical evaluation of vestibulo-suppressive drugs.
观察到两种抗胆碱能药物之间存在显著差异。阿托品仅改变慢相（mes）的眼速，而东莨菪碱改变了所测量的两个参数，即mes和持续时间。苯丙胺和咖啡因延长了持续时间，而mes未改变。所有止吐药物均抑制了这两个参数。得出的结论是，在对前庭抑制药物的临床前评估中，药物对冷热反应的影响提供的信息不足。
