氟桂利嗪和桂利嗪作为前庭抑制剂的一项统计学研究。

Flunarizine and cinnarizine as vestibular depressants. A statistical study.

作者信息

Mangabeira-Albernaz P L, Ganança M M, Novo N F, de Paiva E R

出版信息

ORL J Otorhinolaryngol Relat Spec. 1978;40(2):92-100. doi: 10.1159/000275391.

Abstract

The authors analysed the vestibular depressant activity of flunarizine and cinnarizine, as compared to a placebo, in 58 patients with peripheral labyrinthine disorders. The activity of the medications was judged by the reduction of the average velocity of the slow phase of the post-caloric nystagmus, before and after treatment. In spite of being administered in a smaller dosis, flunarizine appeared to have a more intense vestibular supressant activity, as judged by different statistical tests.

摘要

作者分析了氟桂利嗪和桂利嗪与安慰剂相比，在58例外周性迷路疾病患者中的前庭抑制活性。通过治疗前后冷热试验后眼震慢相平均速度的降低来判断药物的活性。尽管氟桂利嗪的给药剂量较小，但通过不同的统计学检验判断，其前庭抑制活性似乎更强。