Department of Molecular Medicine, Unit of Pathology, University of Pavia, and Foundation IRCCS Policlinico San Matteo, Via Forlanini 16, 27100, Pavia, Italy.
PhD in Experimental Medicine, University of Pavia, Corso di Strada Nuova, 27100, Pavia, Italy.
Head Neck Pathol. 2020 Sep;14(3):799-802. doi: 10.1007/s12105-019-01067-5. Epub 2019 Aug 31.
In 2015, Lewis et al. first described low-grade papillary Scheneiderian carcinoma (LGPSC) of the sinonasal tract. Their case resembled a sinonasal papilloma clinically and histopathologically; however, invasion and metastasis resulted in the death of the patient despite absence of malignant cytologic features. Additional reports established LGPSC as a distinct entity and characterized its immunohistochemical profile. Diffuse expression of low molecular weight cytokeratins, positivity for p16 and p53 in at least 50% of cells, a high Ki-67 index, and absence of human papillomavirus (HPV)-DNA was observed across all reported cases. We report an additional case of LGPSC and describe the clinical, histologic, and immunohistochemical features. In contrast to sinonasal papillomas, the case was negative for HPV-DNA and showed no mutations in the EGFR and KRAS hotspot regions.
2015 年，Lewis 等人首次描述了鼻窦的低级别柱状 Schneiderian 癌（LGPSC）。他们的病例在临床上和组织病理学上类似于鼻窦乳头状瘤；然而，由于存在侵袭和转移，尽管没有恶性细胞学特征，但患者还是死亡了。其他报道将 LGPSC 确立为一种独特的实体，并描述了其免疫组织化学特征。在所有报道的病例中，均观察到低分子量细胞角蛋白弥漫表达、至少 50%的细胞 p16 和 p53 阳性、Ki-67 指数高以及无人类乳头瘤病毒（HPV）-DNA。我们报告了另外一个 LGPSC 病例，并描述了其临床、组织学和免疫组织化学特征。与鼻窦乳头状瘤不同，该病例 HPV-DNA 为阴性，且在 EGFR 和 KRAS 热点区域没有突变。
