Department of Psychology, University of Alabama at Birmingham, CIRC 235G, 1719 6th Ave South, Birmingham, AL, 35294-0021, USA.
J Autism Dev Disord. 2019 Nov;49(11):4498-4514. doi: 10.1007/s10803-019-04168-w.
There is growing evidence of altered connectivity in autism spectrum disorders (ASD) between the cerebellum and cortex. Three intrinsic connectivity networks (ICNs) are especially important to cognitive processing in ASD: the default mode network (DMN), executive control network (ECN), and salience networks (SNs). The goal of this study was to compare resting-state functional connectivity between the cerebellum and the DMN, ECN, and SN in ASD and typically developing children (n = 74, ages 7-12 years). Children with ASD showed stronger connectivity between the ventral DMN and left cerebellar lobules I-IV. No meaningful relationships were observed between ICN-cerebellar functional connectivity and ASD symptoms. These results suggest that the cerebellum contributes to altered network connectivity in ASD.
越来越多的证据表明，自闭症谱系障碍（ASD）患者的小脑和大脑皮层之间存在连接异常。三个内在连接网络（ICNs）对 ASD 患者的认知处理尤为重要：默认模式网络（DMN）、执行控制网络（ECN）和突显网络（SN）。本研究的目的是比较 ASD 和正常发育儿童（n=74，年龄 7-12 岁）静息状态下小脑与 DMN、ECN 和 SN 之间的功能连接。与对照组相比，ASD 患儿的腹侧 DMN 与左侧小脑小叶 I-IV 之间的连接更强。未观察到 ICN-小脑功能连接与 ASD 症状之间存在有意义的关系。这些结果表明，小脑对 ASD 中的网络连接异常有贡献。
