依他尼酸对外周性前庭眼球震颤的作用。

Effect of ethacrynic acid upon the peripheral vestibular nystagmus.

作者信息

Kusakari J, Sato Y, Kobayashi T, Saijo S, Kawamoto K

出版信息

Adv Otorhinolaryngol. 1979;25:178-83. doi: 10.1159/000402939.

Abstract

The effect of ethacrynic acid (ETA) upon pendular rotation nystagmus and paralytic nystagmus was examined using 61 guinea pigs. 100 mg/kg ETA reduced these nystagmus but 30 mg/kg ETA had on effect. Galvanic nystagmus, Bechterew's compensatory nystagmus, OKN and EEG were not affected by 100 ng/kg ETA. These results are highly suggestive that the inhibition of the peripheral vestibular nystagmus by ETA is mainly due to the reduction of the ampullar endolymphatic potential.

摘要

使用61只豚鼠研究了依他尼酸（ETA）对摆动性旋转性眼球震颤和麻痹性眼球震颤的影响。100mg/kg的ETA可减轻这些眼球震颤，但30mg/kg的ETA则无作用。100ng/kg的ETA对电流性眼球震颤、别赫捷列夫氏代偿性眼球震颤、视动性眼球震颤和脑电图均无影响。这些结果强烈提示，ETA对外周前庭性眼球震颤的抑制作用主要是由于壶腹嵴内淋巴电位的降低。