Department of Pathology, Kingmed Diagnostics, Nanjing, Jiangsu Province, China.
Department of Pathology, Traditional Chinese Medicine Hospital of Dafeng City, Yancheng, Jiangsu Province, China.
Thorac Cancer. 2019 Oct;10(10):2054-2056. doi: 10.1111/1759-7714.13190. Epub 2019 Sep 1.
Leiomyosarcoma with osteoclast-like giant cells (LMS-OGC) has seldom been reported clinically. LMS-OGC of the breast is extremely rare according to the literature. Here, we report a case of LMS-OGC leiomyosarcoma with osteoclast-like giant cells of the breast. A 51-year-old female patient presented with a breast mass which was treated surgically and the pathological examination of the tumor indicated LMS-OGC. Microscopically, the tumor was composed of spindle cells arranged in bundles or spokes with giant tumor cells and mitosis. Eosinophilic cytoplasm and morphologically benign osteoclast-like cells were mixed together. Immunohistochemistry examination revealed SMA and desmin were positive with a Ki-67 proliferation index of 40%. However, CK (AE1/AE3), E-cadherin, ER, PR, CD34, S-100 and CD10 were negatively expressed in the tumor tissue. LMS-OGC is a soft tissue malignant tumor which develops extremely rarely in the breast. It should be differentiated and diagnosed according to the history, histological characteristics and immunohistochemical staining.
伴有破骨样巨细胞的平滑肌肉瘤（LMS-OGC）在临床上很少见。根据文献报道，乳腺 LMS-OGC 极为罕见。本文报道 1 例乳腺伴有破骨样巨细胞的 LMS-OGC 平滑肌肉瘤。患者为 51 岁女性，因乳腺肿块就诊，行手术治疗，肿瘤的病理检查提示为 LMS-OGC。镜下，肿瘤由梭形细胞束或轮辐状排列组成，伴有巨细胞和有丝分裂。细胞质嗜酸性，形态上良性的破骨样细胞混合在一起。免疫组化检查显示 SMA 和 desmin 阳性，Ki-67 增殖指数为 40%。然而，肿瘤组织 CK（AE1/AE3）、E-cadherin、ER、PR、CD34、S-100 和 CD10 均阴性表达。LMS-OGC 是一种软组织恶性肿瘤，在乳腺中极罕见。应根据病史、组织学特征和免疫组化染色进行鉴别诊断。
