Lv Haoqiang, Ren Haiyang, Zhang Shuang, Ding Gen, Tian Ping
Department of General Surgery, Beidahuang Group Hongxinglong Hospital, Shuangyashan, Heilongjiang, China.
Department of General Surgery, Linyi Maternity and Child Health Care Hospital, Linyi, Shandong, China.
Front Oncol. 2025 May 22;15:1571029. doi: 10.3389/fonc.2025.1571029. eCollection 2025.
Primary leiomyosarcoma of the breast is an extremely rare tumor originating from the mesenchymal tissue of the breast. The clinical data of a case of primary leiomyosarcoma of the breast admitted to our hospital on September 11, 2024 were analyzed. A 58-year-old woman had a right breast mass for a week. Physical examination revealed an irregular mass at approximately 2-3 points in the right upper quadrant of the breast. Laboratory tests showed normal results for the tumor marker CA153. Color Doppler ultrasound considered solid nodules (BI-RADS Class 4b). Modified radical mastectomy and tertiary axillary lymph node dissection was performed on 2024-9-13, and the patient underwent adjuvant chemotherapy after surgery and recovered well. Pathological findings were reported one week after surgery: breast leiomyosarcoma. This article presents the diagnosis and treatment of primary leiomyosarcoma of breast through a clinical case, which provides a reference for clinicians. This case highlights the importance of pathological examination in the diagnosis of rare tumors, and suggests the need to combine imaging, laboratory examination and pathological findings to make a comprehensive judgment of breast masses.
原发性乳腺平滑肌肉瘤是一种极为罕见的起源于乳腺间叶组织的肿瘤。对我院于2024年9月11日收治的1例原发性乳腺平滑肌肉瘤患者的临床资料进行分析。一名58岁女性发现右乳肿块一周。体格检查发现右乳外上象限约2-3点处有一不规则肿块。实验室检查显示肿瘤标志物CA153结果正常。彩色多普勒超声考虑为实性结节（BI-RADS 4b类）。于2024年9月13日行改良根治性乳房切除术及三级腋窝淋巴结清扫术，患者术后接受辅助化疗，恢复良好。术后一周报告病理结果：乳腺平滑肌肉瘤。本文通过1例临床病例介绍原发性乳腺平滑肌肉瘤的诊断与治疗，为临床医生提供参考。该病例突出了病理检查在罕见肿瘤诊断中的重要性，并提示需要结合影像学、实验室检查及病理结果对乳腺肿块进行综合判断。
