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[重庆农村地区学龄儿童血铅水平及其与行为的关系]

[The blood lead level and its relationship with behavior in school-age children from rural areas of Chongqing].

作者信息

Zeng H, Wang L Q, Xiang M L, Tan Y, Wang J, Chen J A, Zhou Z Y, Luo J H, Huang Y J, Lyu C, Rong H H, Shu W Q, Qiu Z Q

机构信息

Department of Environmental Hygiene, College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.

Department of Health Education, College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Sep 6;53(9):907-912. doi: 10.3760/cma.j.issn.0253-9624.2019.09.008.

DOI:10.3760/cma.j.issn.0253-9624.2019.09.008
PMID:31474072
Abstract

To explore the blood lead level and its relationship with behavior in school-age children from rural areas of Chongqing. A total of 697 students from grades 3 to 6 in the fall semester of 2014 from 14 rural townships in one district of Chongqing was selected by using the random cluster sampling method. Blood were sampled to analyze the lead level. Neurobehavioral tests were performed to determine their personal cognitive and memory ability. Questionnaires and physical examinations were administered to obtain the information of confounding factors. All students were divided into - groups according to the quartile of their blood lead level. The relationship between the blood lead level and behavior was analyzed by multivariate logistic regression model and restricted spline regression model. The mean age of 697 students was (10.07±1.36) years old, and the median (interquartile range) of their blood lead level was 44.31 (35.42) μg/L. Multivariate logistic regression model showed that after adjusting for age, gender, body mass index and maternal culture level, compared with group, the (95) values of high digit symbol substitution test (DSST) scores and high overall memory quotient (MQ) scores in group were 1.65 (1.01-2.70) and 2.10 (1.21-3.62), and the (95) value of high long term memory (LTM) scores in group was 0.53 (0.31-0.92). The results of the restricted spline regression model showed that the dose-response curves between the blood lead level and MQ/LTM test scores were both parabolic (0.05). The blood lead level of school-age children from rural areas of Chongqing is the same as that from other areas of China, but slightly higher than that from other areas of Chongqing. Children with higher blood lead level have poor long-term memory ability.

摘要

探索重庆农村地区学龄儿童的血铅水平及其与行为的关系。采用随机整群抽样方法,选取了重庆市某区14个农村乡镇2014年秋季学期三至六年级的697名学生。采集血样分析铅水平。进行神经行为测试以确定他们的个人认知和记忆能力。通过问卷调查和体格检查获取混杂因素信息。所有学生根据血铅水平四分位数分组。采用多因素logistic回归模型和限制性样条回归模型分析血铅水平与行为的关系。697名学生的平均年龄为(10.07±1.36)岁,血铅水平中位数(四分位间距)为44.31(35.42)μg/L。多因素logistic回归模型显示,在调整年龄、性别、体重指数和母亲文化程度后,与低血铅组相比,高血铅组数字符号替换测验(DSST)高分值和总记忆商(MQ)高分值的比值比(95%可信区间)分别为1.65(1.01 - 2.70)和2.10(1.21 - 3.62),高血铅组长时记忆(LTM)高分值的比值比(95%可信区间)为0.53(0.31 - 0.92)。限制性样条回归模型结果显示,血铅水平与MQ/LTM测试分数之间的剂量反应曲线均为抛物线形(P<0.05)。重庆农村地区学龄儿童血铅水平与我国其他地区相当,但略高于重庆其他地区。血铅水平较高的儿童长期记忆能力较差。

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