Department of Radiation Oncology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital , Chongqing Province , People's Republic of China.
Chongqing Key Laboratory of Traditional Chinese Medicine to Prevent and Treat Autoimmune Diseases, Chongqing Hospital of Traditional Chinese Medicine , Chongqing Province , People's Republic of China.
Cancer Invest. 2019;37(8):376-386. doi: 10.1080/07357907.2019.1656730. Epub 2019 Sep 2.
This meta-analysis aims to evaluate the effectiveness of chemotherapy before (I-CRT) or after (CRT-C) chemoradiotherapy (CRT) for inoperable locally advanced non-small cell lung cancer (LA-NSCLC). According to the object response rate (ORR) and disease control rate (DCR), there were no differences among I-CRT, CRT, and CRT-C treatments. I-CRT did not have significant survival benefits compared with CRT alone. Similar results comparing CRT-C with CRT were observed. Furthermore, I-CRT was not associated with improved survival compared to CRT-C with respect to OS and PFS. Our meta-analysis suggests the effects of additional chemotherapy added to CRT were limited for unselected LA-NSCLC.
本荟萃分析旨在评估不可手术局部晚期非小细胞肺癌（LA-NSCLC）患者在放化疗（CRT）前（I-CRT）或后（CRT-C）进行化疗的疗效。根据客观缓解率（ORR）和疾病控制率（DCR），I-CRT、CRT 和 CRT-C 治疗之间无差异。与单独 CRT 相比，I-CRT 并未显示出明显的生存获益。CRT-C 与 CRT 之间的比较也观察到了类似的结果。此外，I-CRT 与 CRT-C 相比，OS 和 PFS 方面的生存改善也没有差异。本荟萃分析表明，对于未选择的 LA-NSCLC，额外化疗加用 CRT 的效果有限。
