al Muzairai I A, MacLeod A M, Innes A, Cunningham C, Stewart K N, Power D A, Catto G R
Department of Medicine and Therapeutics, University of Aberdeen, UK.
Nephrol Dial Transplant. 1988;3(6):803-8.
Antiidiotypic activity was determined in non-cytotoxic sera from highly sensitised dialysis patients who previously possessed broad-spectrum lymphocytotoxic antibodies. At least four non-cytotoxic sera from six transfused patients were tested in the short antiidiotypic antibody assay against lymphocytes known to be lysed by cytotoxic sera from the same patient. Of 87 sera/cell combinations studied, antiidiotypic activity was detected in 42 (48%). Antiidiotypic activity was present in IgG fractions and F(ab')2 fragments of two active sera. These results indicate that non-cytotoxic sera from patients who were once highly sensitised possess antiidiotypic activity. Fluctuating levels of lymphocytotoxic antibodies frequently encountered in sera from dialysis patients may be explained at least in part by the development of antiidiotypic antibodies.
在先前拥有广谱淋巴细胞毒性抗体的高度致敏透析患者的无细胞毒性血清中测定抗独特型活性。在短抗独特型抗体检测中，对来自6名输血患者的至少4份无细胞毒性血清进行了检测，检测对象是已知会被同一患者的细胞毒性血清裂解的淋巴细胞。在研究的87种血清/细胞组合中，42种（48%）检测到抗独特型活性。两种活性血清的IgG组分和F(ab')2片段中存在抗独特型活性。这些结果表明，曾经高度致敏患者的无细胞毒性血清具有抗独特型活性。透析患者血清中经常遇到的淋巴细胞毒性抗体水平波动，至少部分可以用抗独特型抗体的产生来解释。
