UGC de Reumatología, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España.
Hospital Universitario Virgen de las Nieves, Granada, España.
Reumatol Clin (Engl Ed). 2021 Apr;17(4):197-202. doi: 10.1016/j.reuma.2019.06.001. Epub 2019 Aug 29.
To study the differences between rheumatoid arthritis (RA)-interstitial lung disease (ILD) patients and RA patients without ILD in severity markers and disease activity and to identify factors associated with the presence of ILD in RA patients.
Patients: RA-ILD patients selected from a multicentre cohort in Andalusia, Spain.
RA-patients without ILD paired by sex, age and disease duration.
RA patients are reviewed every 3-6months in rheumatology consultation. All patients are reviewed according to a predetermined protocol with systematic data collection.
description of ILD type, differences in severity markers and disease activity in both groups. Other variables: ILD type by imaging technique (HRCT): nonspecific interstitial pneumonia (NSIP)/usual interstitial pneumonia (UIP). Lung function by PTF. Activity and severity markers of arthritis by DAS28-ESR, HAQ, RF, ACPA and erosions. Treatment with DMARD.
descriptive and paired T-test or Chi-square test followed by binary logistic regression (DV: ILD in patients with RA).
Eighty-two patients were included, 41 RA-ILD and 41 RA controls. RF and ACPA positivity, serositis and osteoporosis were more frequent in RA-ILD patients. No significant differences in DAS28 were observed (P=.145) between RA-ILD and RA control patients. RA-ILD patients presented worse HAQ scores (P=.006). All patients were treated with disease modifying antirheumatic drugs (DMARDs). The risk of developing ILD in RA patients is tripled by a history of smoking or the presence of erosive arthritis (R=.36).
The results of our study support the higher frequency of UIP and NSIP in RA patients. DLCO is the most sensitive parameter to detect ILD in RA patients. Our study showed that ILD in RA patients was associated with RA severity (presence of erosions and ACPA) and with a history of smoking.
研究类风湿关节炎（RA）-间质性肺疾病（ILD）患者与无ILD 的 RA 患者在严重程度标志物和疾病活动度方面的差异，并确定 RA 患者ILD 存在的相关因素。
患者：从西班牙安达卢西亚的一个多中心队列中选择的 RA-ILD 患者。
性别、年龄和疾病持续时间匹配的无ILD 的 RA 患者。
RA 患者每 3-6 个月在风湿病门诊进行一次复查。所有患者均根据预定方案进行复查，系统收集数据。
描述ILD 类型、两组间严重程度标志物和疾病活动度的差异。其他变量：影像学技术（HRCT）下的ILD 类型：非特异性间质性肺炎（NSIP）/寻常性间质性肺炎（UIP）。PTF 下的肺功能。DAS28-ESR、HAQ、RF、ACPA 和侵蚀的关节炎活动度和严重程度标志物。DMARD 治疗。
描述性和配对 t 检验或卡方检验，然后进行二元逻辑回归（DV：RA 患者的ILD）。
共纳入 82 例患者，其中 41 例 RA-ILD 和 41 例 RA 对照组。RF 和 ACPA 阳性、浆膜炎和骨质疏松症在 RA-ILD 患者中更为常见。RA-ILD 和 RA 对照组患者的 DAS28 无显著差异（P=.145）。RA-ILD 患者的 HAQ 评分较差（P=.006）。所有患者均接受了疾病修饰抗风湿药物（DMARDs）治疗。吸烟史或侵蚀性关节炎的存在使 RA 患者发生 ILD 的风险增加两倍（R=.36）。
我们的研究结果支持 RA 患者中 UIP 和 NSIP 的更高频率。DLCO 是检测 RA 患者ILD 的最敏感参数。我们的研究表明，RA 患者的 ILD 与 RA 的严重程度（侵蚀和 ACPA 的存在）以及吸烟史有关。
