Brain delivery of a virus to block seizures helps mice get a silent NACHT.
作者信息
Henshall David C
机构信息
Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland; FutureNeuro Research Centre, RCSI, Dublin, Ireland.
出版信息
EBioMedicine. 2019 Sep;47:8-9. doi: 10.1016/j.ebiom.2019.08.066. Epub 2019 Aug 29.
Abstract
摘要
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本文引用的文献
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Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.抑制 Nwd1 活性可减轻海马神经元过度兴奋和 GluN2B 磷酸化。
EBioMedicine. 2019 Sep;47:470-483. doi: 10.1016/j.ebiom.2019.08.050. Epub 2019 Aug 29.
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Gene Therapy.基因治疗
N Engl J Med. 2019 Aug 1;381(5):455-464. doi: 10.1056/NEJMra1706910.
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Expression profile of the STAND protein Nwd1 in the developing and mature mouse central nervous system.STAND 蛋白 Nwd1 在发育中和成熟的小鼠中枢神经系统中的表达谱。
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New avenues for anti-epileptic drug discovery and development.抗癫痫药物发现和开发的新途径。
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Drug-resistant epilepsy.耐药性癫痫
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The role of inflammation in epilepsy.炎症在癫痫中的作用。
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NLRs join TLRs as innate sensors of pathogens.NLRs与TLRs一样，都是病原体的天然感受器。
Trends Immunol. 2005 Aug;26(8):447-54. doi: 10.1016/j.it.2005.06.004.
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Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death.在癫痫发作诱导的神经元死亡过程中，Apaf-1/细胞色素c复合物的形成先于半胱天冬酶-9的激活。
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