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本文引用的文献

1
Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.抑制 Nwd1 活性可减轻海马神经元过度兴奋和 GluN2B 磷酸化。
EBioMedicine. 2019 Sep;47:470-483. doi: 10.1016/j.ebiom.2019.08.050. Epub 2019 Aug 29.
2
Gene Therapy.基因治疗
N Engl J Med. 2019 Aug 1;381(5):455-464. doi: 10.1056/NEJMra1706910.
3
Expression profile of the STAND protein Nwd1 in the developing and mature mouse central nervous system.STAND 蛋白 Nwd1 在发育中和成熟的小鼠中枢神经系统中的表达谱。
J Comp Neurol. 2018 Sep 1;526(13):2099-2114. doi: 10.1002/cne.24495. Epub 2018 Jul 23.
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New avenues for anti-epileptic drug discovery and development.抗癫痫药物发现和开发的新途径。
Nat Rev Drug Discov. 2013 Oct;12(10):757-76. doi: 10.1038/nrd4126. Epub 2013 Sep 20.
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Drug-resistant epilepsy.耐药性癫痫
N Engl J Med. 2011 Sep 8;365(10):919-26. doi: 10.1056/NEJMra1004418.
6
The role of inflammation in epilepsy.炎症在癫痫中的作用。
Nat Rev Neurol. 2011 Jan;7(1):31-40. doi: 10.1038/nrneurol.2010.178. Epub 2010 Dec 7.
7
NLRs join TLRs as innate sensors of pathogens.NLRs与TLRs一样，都是病原体的天然感受器。
Trends Immunol. 2005 Aug;26(8):447-54. doi: 10.1016/j.it.2005.06.004.
8
Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?为什么N-甲基-D-天冬氨酸（NMDA）受体拮抗剂在中风和创伤性脑损伤的临床试验中失败了？
Lancet Neurol. 2002 Oct;1(6):383-6. doi: 10.1016/s1474-4422(02)00164-3.
9
Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death.在癫痫发作诱导的神经元死亡过程中，Apaf-1/细胞色素c复合物的形成先于半胱天冬酶-9的激活。
Cell Death Differ. 2001 Dec;8(12):1169-81. doi: 10.1038/sj.cdd.4400921.
10
The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation.
Trends Biochem Sci. 2000 May;25(5):223-4. doi: 10.1016/s0968-0004(00)01577-2.

Brain delivery of a virus to block seizures helps mice get a silent NACHT.

作者信息

Henshall David C

机构信息

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland; FutureNeuro Research Centre, RCSI, Dublin, Ireland.

出版信息

EBioMedicine. 2019 Sep;47:8-9. doi: 10.1016/j.ebiom.2019.08.066. Epub 2019 Aug 29.

DOI:10.1016/j.ebiom.2019.08.066
PMID:31474550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6796494/
Abstract
摘要