Liu Shiying, Liu Yuxiu, Wan Bo, Zhang Haoyang, Wu Sumei, Zhu Zheng, Lin Yanjie, Wang Mingfang, Zhang Nanwen, Lin Su, Zhu Yueyong
Liver Research Center, the First Affiliated Hospital of Fujian Medical University.
The First Clinical Medical Collage of Fujian Medical University.
J Nutr Sci Vitaminol (Tokyo). 2019;65(4):303-308. doi: 10.3177/jnsv.65.303.
The relationship between vitamin D levels and non-alcoholic fatty liver disease (NAFLD) remains unestablished. In this study, we aimed to explore the relationship between vitamin D levels and NAFLD based on population survey data. This cross-sectional study was conducted based on data from the National Health and Nutrition Examination Survey. Liver steatosis was diagnosed by ultrasonography. Binary logistic regression analyses were performed to determine the relationship between vitamin D status and NAFLD. A total of 9,782 participants were identified in this analysis, with 46.8% male and an average age of 44.41±0.16 y old. Among them, 6,047 (61.8%) cases were without NAFLD, 1,357 (13.9%) had mild NAFLD, 1,594 (16.3%) had moderate and 784 (8.0%) had severe NAFLD. Compared to those with non-NAFLD or mild NAFLD, patients in the moderate to severe NAFLD group had higher vitamin D deficiency or insufficiency rates (12.4% vs 11.5% and 36.8% vs 33.2%, respectively). After adjustment for male gender, older age, race, BMI, history of diabetes and vitamin D intake, vitamin D levels were independently associated with the severity of NAFLD (vitamin D deficiency group OR: 1.314, 95% CI: 1.129 to 1.529, vitamin D insufficiency group OR: 1.203, 95% CI: 1.090 to 1.328). Besides that, cold season was also found to be an independent factor for NAFLD (OR: 0.896, 95% CI: 0.820 to 0.979). Lower vitamin D level is an independent risk factor for NAFLD. Vitamin D levels are inversely associated with the severity of NAFLD. Cold season increases the risk of NAFLD independently.
维生素D水平与非酒精性脂肪性肝病（NAFLD）之间的关系尚未明确。在本研究中，我们旨在基于人群调查数据探索维生素D水平与NAFLD之间的关系。这项横断面研究是基于美国国家健康和营养检查调查的数据进行的。肝脂肪变性通过超声检查诊断。进行二元逻辑回归分析以确定维生素D状态与NAFLD之间的关系。本分析共纳入9782名参与者，其中男性占46.8%，平均年龄为44.41±0.16岁。其中，6047例（61.8%）无NAFLD，1357例（13.9%）患有轻度NAFLD，1594例（16.3%）患有中度NAFLD，784例（8.0%）患有重度NAFLD。与非NAFLD或轻度NAFLD患者相比，中重度NAFLD组患者的维生素D缺乏或不足率更高（分别为12.4%对11.5%和36.8%对33.2%）。在调整了男性性别、年龄较大、种族、BMI、糖尿病史和维生素D摄入量后，维生素D水平与NAFLD的严重程度独立相关（维生素D缺乏组OR：1.314，95%CI：1.129至1.529；维生素D不足组OR：1.203，95%CI：1.090至1.328）。除此之外，还发现寒冷季节是NAFLD的一个独立因素（OR：0.896，95%CI：0.820至0.979）。较低的维生素D水平是NAFLD的一个独立危险因素。维生素D水平与NAFLD的严重程度呈负相关。寒冷季节独立增加NAFLD的风险。
