Michaelis R C, Holohean A M, Criado J R, Harland R D, Hunter G A, Holloway F A
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Psychopharmacology (Berl). 1988;96(1):15-20. doi: 10.1007/BF02431527.
Rats were trained to discriminate chlordiazepoxide (CDP) from pentylenetetrazol (PTZ) in a two-lever food motivated discrimination task. Training drug doses were adjusted until subjects emitted approximately 50% of their responses on each of the two drug-appropriate levers during saline injection tests. Tests that followed injection of CDP/PTZ combinations illustrated a reciprocal antagonism between the two drugs. Saline-injection tests that followed large dose injections of CDP revealed a period of predominantly PTZ-appropriate responding that persisted after the initial period of predominantly CDP-appropriate responding. These data are interpreted to suggest that, unlike some other drugs that have been shown to antagonize the behavioral and CNS effects of benzodiazepines, the interoceptive stimulus generated by PTZ occupies a position opposite to that of CDP along some single affective continuum. In addition, these data suggest that drug/drug (DD) discriminations are capable of characterizing the interactions between training drugs. Finally, the data suggest that the CDP/PTZ discrimination is a sensitive detector of bidirectional shifts in interoceptive stimulus state along the CDP/PTZ continuum.
在一项双杠杆食物驱动的辨别任务中，训练大鼠区分氯氮卓（CDP）和戊四氮（PTZ）。调整训练药物剂量，直到在盐水注射测试期间，受试者在两个与药物匹配的杠杆上各发出约50%的反应。注射CDP/PTZ组合后的测试表明这两种药物之间存在相互拮抗作用。大剂量注射CDP后的盐水注射测试显示，在最初主要是与CDP匹配的反应期之后，出现了一段主要是与PTZ匹配的反应期。这些数据被解释为表明，与其他一些已被证明能拮抗苯二氮卓类药物行为和中枢神经系统作用的药物不同，PTZ产生的内感受性刺激在某个单一情感连续体上占据与CDP相反的位置。此外，这些数据表明药物/药物（DD）辨别能够表征训练药物之间的相互作用。最后，数据表明CDP/PTZ辨别是内感受性刺激状态沿CDP/PTZ连续体双向变化的灵敏探测器。
