降压药与慢性胰腺炎患者胰腺癌风险：一项丹麦全国基于人群的队列研究。
Antihypertensive drugs and pancreatic cancer risk in patients with chronic pancreatitis: a Danish nationwide population-based cohort study.
机构信息
Department of Surgery, Section for Hepato-Pancreato-Biliary Surgery, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Br J Cancer. 2019 Oct;121(7):622-624. doi: 10.1038/s41416-019-0562-y. Epub 2019 Sep 2.
BACKGROUND
Antihypertensives may inhibit pancreatic carcinogenesis. We examined the association between use of these drugs and pancreatic cancer in patients with chronic pancreatitis.
METHODS
We conducted a nationwide population-based cohort study of all chronic pancreatitis patients diagnosed in Denmark during 1996-2012. Using a Cox proportional hazards model with time-varying exposure lagged by 1 year, we examined the risk of pancreatic cancer according to antihypertensive drug use.
RESULTS
We included 8,311 patients with chronic pancreatitis and observed 153 pancreatic cancers during follow-up. At baseline, 2197 patients (26.4%) were exposed to at least one class of antihypertensive drugs. We did not observe any measurable associations between the use of antihypertensive drugs and pancreatic cancer.
CONCLUSIONS
Our findings suggest little evidence of an association between the use of antihypertensive drugs and pancreatic cancer risk in patients with chronic pancreatitis. Confirmation is warranted in future studies.
背景
降压药可能抑制胰腺癌的发生。我们研究了这些药物的使用与慢性胰腺炎患者胰腺癌之间的关系。
方法
我们对丹麦在 1996 年至 2012 年间诊断的所有慢性胰腺炎患者进行了一项全国性基于人群的队列研究。使用时变暴露滞后 1 年的 Cox 比例风险模型，我们根据降压药物的使用情况检查了胰腺癌的风险。
结果
我们纳入了 8311 例慢性胰腺炎患者，在随访期间观察到 153 例胰腺癌。基线时有 2197 例（26.4%）患者至少使用了一类降压药。我们没有观察到降压药物的使用与胰腺癌之间存在任何可衡量的关联。
结论
我们的研究结果表明，降压药物的使用与慢性胰腺炎患者的胰腺癌风险之间几乎没有关联。在未来的研究中需要进一步证实。
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