Willingham T Bradley, Melbourn Jonathan, Moldavskiy Marina, McCully Kevin K, Backus Deborah
Int J MS Care. 2019 Jul-Aug;21(4):166-172. doi: 10.7224/1537-2073.2018-021.
Exercise can improve muscle function and mobility in people with multiple sclerosis (MS). However, the effects of exercise training on skeletal muscle oxidative capacity and endurance in people with MS remain unclear, and few studies have evaluated muscle plasticity in people with MS who have moderate-to-severe disability. The present study evaluated the effects of treadmill training on muscle oxidative capacity and muscle endurance and examined the relationship to walking function in people with MS who have moderate-to-severe disability.
Six adults (mean ± SD age, 50 ± 4.9 years) with MS (Expanded Disability Status Scale score, 6.0-6.5) performed treadmill training for 24 minutes approximately twice per week for approximately 8 weeks (16 sessions total) using an antigravity treadmill system. The following measures were taken before and after the intervention phase: muscle oxidative capacity in the medial gastrocnemius using near-infrared spectroscopy after 15 to 20 seconds of electrical stimulation; muscle endurance in the medial gastrocnemius using accelerometer-based mechanomyography during 9 minutes of twitch electrical stimulation in three stages (3 minutes per stage) of increasing frequency (2, 4, and 6 Hz); and walking function using the 2-Minute Walk Test.
Mean ± SD muscle oxidative capacity increased from 0.64 ± 0.19 min to 1.08 ± 0.52 min (68.2%). Mean ± SD muscle endurance increased from 80.9% ± 15.2% to 91.5% ± 4.8% at 2 Hz, from 56.3% ± 20.1% to 76.6% ± 15.8% at 4 Hz, and from 29.2% ± 13.1% to 53.9% ± 19.4% at 6 Hz of stimulation in the gastrocnemius. There were no significant improvements in walking function.
Treadmill training can improve muscle oxidative capacity and endurance in people with MS who have moderate-to-severe levels of disability.
运动可以改善多发性硬化症（MS）患者的肌肉功能和活动能力。然而，运动训练对MS患者骨骼肌氧化能力和耐力的影响仍不明确，并且很少有研究评估中重度残疾的MS患者的肌肉可塑性。本研究评估了跑步机训练对中重度残疾的MS患者肌肉氧化能力和肌肉耐力的影响，并探讨了其与步行功能的关系。
6名成年MS患者（平均年龄±标准差，50±4.9岁；扩展残疾状态量表评分，6.0 - 6.5）使用反重力跑步机系统，每周约两次，每次进行24分钟的跑步机训练，共约8周（总计16次训练）。在干预阶段前后进行以下测量：在15至20秒电刺激后，使用近红外光谱法测量腓肠肌内侧的肌肉氧化能力；在9分钟的抽搐电刺激过程中，分三个阶段（每个阶段3分钟）以递增频率（2、4和6赫兹）使用基于加速度计的肌动图测量腓肠肌内侧的肌肉耐力；使用2分钟步行测试评估步行功能。
平均±标准差的肌肉氧化能力从0.64±0.19分钟增加到1.08±0.52分钟（增加了68.2%）。在腓肠肌中，刺激频率为2赫兹时，平均±标准差的肌肉耐力从80.9%±15.2%增加到91.5%±4.8%；刺激频率为4赫兹时，从56.3%±20.1%增加到76.6%±15.8%；刺激频率为6赫兹时，从29.2%±13.1%增加到53.9%±19.4%。步行功能没有显著改善。
跑步机训练可以改善中重度残疾的MS患者的肌肉氧化能力和耐力。
