多发性硬化症患者的骨骼肌线粒体能力
Skeletal muscle mitochondrial capacity in people with multiple sclerosis.
作者信息
Harp Mary Ann, McCully Kevin K, Moldavskiy Marina, Backus Deborah
机构信息
Department of Kinesiology, University of Georgia, USA.
Shepherd Center, USA.
出版信息
Mult Scler J Exp Transl Clin. 2016 Nov 15;2:2055217316678020. doi: 10.1177/2055217316678020. eCollection 2016 Jan-Dec.
BACKGROUND
People with multiple sclerosis (MS) have functional disability and may have reduced muscle mitochondrial capacity.
OBJECTIVE
The objective of this paper is to measure muscle mitochondrial capacity of leg muscles using near-infrared spectroscopy (NIRS) and compare to functional status.
MATERIALS AND METHODS
People with MS ( = 16) and a control (CON) group ( = 9) were evaluated for 25-ft walk time. Mitochondrial capacity of both gastrocnemius muscles were measured with NIRS as the rate of recovery of oxygen consumption in after exercise.
RESULTS
Mitochondrial capacity was lower in the MS group compared to the CON group (rate constants: 1.13 ± 0.29 vs. 1.68 ± 0.37 min, < 0.05). There was a tendency for people with MS who used assistive devices to have lower mitochondrial capacity in the weaker leg ( = 0.07).
CONCLUSION
NIRS measurements of mitochondrial capacity suggest a 40% deficit in people with MS compared to CONs and this may contribute to walking disability.
背景
多发性硬化症（MS）患者存在功能残疾，且肌肉线粒体能力可能降低。
目的
本文旨在使用近红外光谱法（NIRS）测量腿部肌肉的线粒体能力，并与功能状态进行比较。
材料与方法
对16名MS患者和9名对照组（CON）进行25英尺步行时间评估。用NIRS测量双侧腓肠肌的线粒体能力，即运动后氧消耗的恢复率。
结果
与CON组相比，MS组的线粒体能力较低（速率常数：1.13±0.29对1.68±0.37分钟，P<0.05）。使用辅助设备的MS患者在较弱的腿部线粒体能力有降低的趋势（P=0.07）。
结论
线粒体能力的NIRS测量表明，与对照组相比，MS患者的线粒体能力有40%的缺陷，这可能导致行走障碍。
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