• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

促甲状腺激素释放激素原基因产物调节花鲈大脑和消化系统的基因表达（）。

TAC3 Gene Products Regulate Brain and Digestive System Gene Expression in the Spotted Sea Bass ().

作者信息

Zhang Zhanxiong, Wen Haishen, Li Yun, Li Qing, Li Wenjuan, Zhou Yangyang, Wang Lingyu, Liu Yang, Lyu Likang, Qi Xin

机构信息

Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, China.

出版信息

Front Endocrinol (Lausanne). 2019 Aug 14;10:556. doi: 10.3389/fendo.2019.00556. eCollection 2019.

DOI:10.3389/fendo.2019.00556
PMID:31474940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6702303/
Abstract

Neurokinin B (NKB) is a member of the () family that plays important roles in mammalian growth by modulating prolactin (PRL) synthesis and secretion and causing contraction of the stomach and intestine. However, its potential role in regulating growth of teleosts is less clear. We aimed to explore the role that NKB plays in regulating fish growth using the spotted sea bass () as a model. In the present study, two and two genes were identified in the spotted sea bass. Sequence analysis showed that two transcripts, and , encode four NKBs: NKBa-13, NKBa-10, NKBb-13, and NKBb-10. Expression analysis in different tissues showed that both genes are highly expressed in the brain, stomach and intestine of the spotted sea bass. hybridization indicated that the and mRNAs are both localized in several brain regions, such as the telencephalon and hypothalamus, and that and are localized in the intestinal villus and gastric gland. To investigate the potential role of NKBs in regulating growth, experiments were performed to detect the effect of NKBs on growth-related gene expression in the brain and brain-gut peptide (BGP)-related genes in the stomach and intestine. NKBb-13 was the most critical ligand in regulating the expression of growth-related genes in the brain and brain-gut peptide (BGP)-related genes in the stomach. The expression of () was enhanced by NKBa-13, NKBa-10, and NKBb-10 but not NKBb-13 in the intestine. In general, our results showed that NKBs participate in regulating the growth of spotted sea bass.

摘要

神经激肽B（NKB）是（）家族的成员，通过调节催乳素（PRL）的合成和分泌以及引起胃和肠道收缩，在哺乳动物生长中发挥重要作用。然而，其在硬骨鱼生长调节中的潜在作用尚不清楚。我们旨在以花鲈（）为模型，探索NKB在调节鱼类生长中所起的作用。在本研究中，在花鲈中鉴定出两个和两个基因。序列分析表明，两个转录本和编码四种NKB：NKBa - 13、NKBa - 10、NKBb - 13和NKBb - 10。不同组织中的表达分析表明，这两个基因在花鲈的脑、胃和肠道中均高度表达。杂交表明，和mRNA均定位于几个脑区，如端脑和下丘脑，并且和定位于肠绒毛和胃腺。为了研究NKB在调节生长中的潜在作用，进行了实验以检测NKB对脑中生长相关基因表达以及胃和肠道中脑肠肽（BGP）相关基因表达的影响。NKBb - 13是调节脑中生长相关基因表达以及胃中脑肠肽（BGP）相关基因表达的最关键配体。在肠道中，NKBa - 13、NKBa - 10和NKBb - 10可增强（）的表达，但NKBb - 13不能。总体而言，我们的结果表明NKB参与调节花鲈的生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/216000300bc6/fendo-10-00556-g0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/a54772f74448/fendo-10-00556-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/5c8b488e6f63/fendo-10-00556-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/82ef74d86b71/fendo-10-00556-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/d03c3ee4e5d4/fendo-10-00556-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/5525be4bd26f/fendo-10-00556-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/ce26660647c8/fendo-10-00556-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/eb4831487c45/fendo-10-00556-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/f3b169a71d97/fendo-10-00556-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/896dd1873e67/fendo-10-00556-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/9421492d60d6/fendo-10-00556-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/536ef2881104/fendo-10-00556-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/0a1979f843bd/fendo-10-00556-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/216000300bc6/fendo-10-00556-g0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/a54772f74448/fendo-10-00556-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/5c8b488e6f63/fendo-10-00556-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/82ef74d86b71/fendo-10-00556-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/d03c3ee4e5d4/fendo-10-00556-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/5525be4bd26f/fendo-10-00556-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/ce26660647c8/fendo-10-00556-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/eb4831487c45/fendo-10-00556-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/f3b169a71d97/fendo-10-00556-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/896dd1873e67/fendo-10-00556-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/9421492d60d6/fendo-10-00556-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/536ef2881104/fendo-10-00556-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/0a1979f843bd/fendo-10-00556-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/6702303/216000300bc6/fendo-10-00556-g0013.jpg

相似文献

1
TAC3 Gene Products Regulate Brain and Digestive System Gene Expression in the Spotted Sea Bass ().促甲状腺激素释放激素原基因产物调节花鲈大脑和消化系统的基因表达（）。
Front Endocrinol (Lausanne). 2019 Aug 14;10:556. doi: 10.3389/fendo.2019.00556. eCollection 2019.
2
TAC3/TACR3 System Function in the Catadromous Migration Teleost, .三碘甲腺原氨酸脱碘酶 3（TAC3/TACR3）系统在洄游性鱼类中的功能。
Front Endocrinol (Lausanne). 2022 Jul 22;13:848808. doi: 10.3389/fendo.2022.848808. eCollection 2022.
3
Goldfish neurokinin B: Cloning, tissue distribution, and potential role in regulating reproduction.金鱼神经激肽B：克隆、组织分布及其在调节生殖中的潜在作用。
Gen Comp Endocrinol. 2015 Sep 15;221:267-77. doi: 10.1016/j.ygcen.2014.10.017. Epub 2014 Nov 14.
4
The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio).脊椎动物速激肽/速激肽受体（TAC/TACR）的进化及斑马鱼（Danio rerio）TAC3/TACR3 系统的分子鉴定。
Mol Cell Endocrinol. 2012 Sep 25;361(1-2):202-12. doi: 10.1016/j.mce.2012.04.007. Epub 2012 May 2.
5
Tachykinin-3 Genes and Peptides Characterized in a Basal Teleost, the European Eel: Evolutionary Perspective and Pituitary Role.速激肽-3基因与肽类在一种基底硬骨鱼——欧洲鳗鲡中的特性：进化视角与垂体作用
Front Endocrinol (Lausanne). 2018 Jun 11;9:304. doi: 10.3389/fendo.2018.00304. eCollection 2018.
6
Evidence for the Direct Effect of the NPFF Peptide on the Expression of Feeding-Related Factors in Spotted Sea Bass ().NPFF肽对花鲈摄食相关因子表达的直接影响的证据（）。
Front Endocrinol (Lausanne). 2019 Aug 6;10:545. doi: 10.3389/fendo.2019.00545. eCollection 2019.
7
Identification, expression analysis, and functional characterization of motilin and its receptor in spotted sea bass (Lateolabrax maculatus).卵形鲳鲹（Lateolabrax maculatus）胃动素及其受体的鉴定、表达分析与功能特征。
Gen Comp Endocrinol. 2019 Jun 1;277:38-48. doi: 10.1016/j.ygcen.2019.02.013. Epub 2019 Feb 13.
8
Neurokinin B signaling in hermaphroditic species, a study of the orange-spotted grouper (Epinephelus coioides).雌雄同体物种中的神经激肽B信号传导：橘点石斑鱼（Epinephelus coioides）的研究
Gen Comp Endocrinol. 2018 May 1;260:125-135. doi: 10.1016/j.ygcen.2018.01.009. Epub 2018 Jan 31.
9
Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in controlling fish reproduction.神经激肽 Bs 和神经激肽 B 受体在斑马鱼中的作用——控制鱼类生殖的潜在作用。
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10269-74. doi: 10.1073/pnas.1119165109. Epub 2012 Jun 11.
10
Knockout of tac3 genes in zebrafish shows no impairment of reproduction.斑马鱼中tac3基因的敲除未显示出生殖功能受损。
Gen Comp Endocrinol. 2021 Sep 15;311:113839. doi: 10.1016/j.ygcen.2021.113839. Epub 2021 Jun 26.

引用本文的文献

1
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists.内源性和类似物肽激动剂激活神经激肽3受体的结构洞察
Cell Discov. 2023 Jun 30;9(1):66. doi: 10.1038/s41421-023-00564-w.
2
Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.速激肽，控制生殖和摄食的新角色：哺乳动物和硬骨鱼类的比较综述。
Front Endocrinol (Lausanne). 2022 Dec 16;13:1056939. doi: 10.3389/fendo.2022.1056939. eCollection 2022.
3
TAC3/TACR3 System Function in the Catadromous Migration Teleost, .

本文引用的文献

1
Identification, expression analysis, and functional characterization of motilin and its receptor in spotted sea bass (Lateolabrax maculatus).卵形鲳鲹（Lateolabrax maculatus）胃动素及其受体的鉴定、表达分析与功能特征。
Gen Comp Endocrinol. 2019 Jun 1;277:38-48. doi: 10.1016/j.ygcen.2019.02.013. Epub 2019 Feb 13.
2
Identification of mapk gene family in Lateolabrax maculatus and their expression profiles in response to hypoxia and salinity challenges.马氏珠母贝 MAPK 基因家族的鉴定及其对低氧和盐度胁迫的表达谱分析。
Gene. 2019 Feb 5;684:20-29. doi: 10.1016/j.gene.2018.10.033. Epub 2018 Oct 15.
3
Neurokinin B signaling in hermaphroditic species, a study of the orange-spotted grouper (Epinephelus coioides).
三碘甲腺原氨酸脱碘酶 3（TAC3/TACR3）系统在洄游性鱼类中的功能。
Front Endocrinol (Lausanne). 2022 Jul 22;13:848808. doi: 10.3389/fendo.2022.848808. eCollection 2022.
4
Response of Pituitary Cells and Tissues to Neurokinin B and F in the Nile tilapia.尼罗罗非鱼垂体细胞和组织对神经激肽B和F的反应。
Dev Reprod. 2022 Mar;26(1):13-21. doi: 10.12717/DR.2022.26.1.13. Epub 2022 Mar 31.
5
Arg-Vasotocin Directly Activates Isotocin Receptors and Induces COX2 Expression in Ovoviviparous Guppies.精氨酸加压素直接激活催产素受体并诱导卵胎生孔雀鱼中 COX2 的表达。
Front Endocrinol (Lausanne). 2021 Apr 23;12:617580. doi: 10.3389/fendo.2021.617580. eCollection 2021.
6
The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish.X 连锁肢端巨大症相关基因 gpr101 是斑马鱼早期胚胎发育和生长的调节剂。
Mol Cell Endocrinol. 2021 Jan 15;520:111091. doi: 10.1016/j.mce.2020.111091. Epub 2020 Nov 26.
7
Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic.速激肽：古老、多样、广泛且功能多效的神经肽
Front Neurosci. 2019 Nov 20;13:1262. doi: 10.3389/fnins.2019.01262. eCollection 2019.
雌雄同体物种中的神经激肽B信号传导：橘点石斑鱼（Epinephelus coioides）的研究
Gen Comp Endocrinol. 2018 May 1;260:125-135. doi: 10.1016/j.ygcen.2018.01.009. Epub 2018 Jan 31.
4
Microbiota-gut-brain axis and the central nervous system.微生物群-肠道-脑轴与中枢神经系统
Oncotarget. 2017 May 10;8(32):53829-53838. doi: 10.18632/oncotarget.17754. eCollection 2017 Aug 8.
5
Neurokinin B regulates reproduction via inhibition of kisspeptin in a teleost, the striped bass.神经激肽B通过抑制硬骨鱼条纹鲈中的吻素调节生殖。
J Endocrinol. 2017 May;233(2):159-174. doi: 10.1530/JOE-16-0575. Epub 2017 Mar 22.
6
Novel Functional Role of NK3R Expression in the Potentiating Effects on Somatolactin α Autoregulation in grass carp pituitary cells.新型 NK3R 表达在增强鲤鱼脑垂体细胞生长激素 α 自身调节中的功能作用。
Sci Rep. 2016 Oct 27;6:36102. doi: 10.1038/srep36102.
7
Goldfish neurokinin B: Cloning, tissue distribution, and potential role in regulating reproduction.金鱼神经激肽B：克隆、组织分布及其在调节生殖中的潜在作用。
Gen Comp Endocrinol. 2015 Sep 15;221:267-77. doi: 10.1016/j.ygcen.2014.10.017. Epub 2014 Nov 14.
8
Transcriptome analysis of the Trachinotus ovatus: identification of reproduction, growth and immune-related genes and microsatellite markers.卵形鲳鲹转录组分析：繁殖、生长和免疫相关基因及微卫星标记的鉴定
PLoS One. 2014 Oct 10;9(10):e109419. doi: 10.1371/journal.pone.0109419. eCollection 2014.
9
Novel pituitary actions of TAC3 gene products in fish model: receptor specificity and signal transduction for prolactin and somatolactin α regulation by neurokinin B (NKB) and NKB-related peptide in carp pituitary cells.鱼类模型中TAC3基因产物的新型垂体作用：鲤鱼垂体细胞中神经激肽B（NKB）和NKB相关肽对催乳素和生长抑素α调节的受体特异性及信号转导
Endocrinology. 2014 Sep;155(9):3582-96. doi: 10.1210/en.2014-1105. Epub 2014 Jun 27.
10
MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.MEGA6：分子进化遗传学分析版本 6.0。
Mol Biol Evol. 2013 Dec;30(12):2725-9. doi: 10.1093/molbev/mst197. Epub 2013 Oct 16.