染色体与人类癌症及白血病的病因。第三十三部分。一例急性淋巴细胞白血病（ALL）中的5号染色体长臂缺失（5q--）

Chromosomes and causation of human cancer and leukemia. XXXIII. 5q-- in a case of acute lymphoblastic leukemia (ALL).

作者信息

Abe S, Kohno S, Kubonishi I, Minowada J, Sandberg A A

出版信息

Am J Hematol. 1979;6(3):259-66. doi: 10.1002/ajh.2830060310.

Abstract

The case of a 4-year-old boy with ALL, possibly developing subsequent to a lymphoma involving the thoracic cavity, which was shown to be of the T-cell type, is presented. The leukemic cells had a 5q-- anomaly, which had previously been described only in cases of refractory anemia and/or AML. The 5q-- abnormality was invariably accompanied by a 9p-- chromosome in the leukemic cells. The interstitial deletion leading to the 5q-- chromosome was shown with banding techniques to be similar to that described previously in myeloproliferative disorders. Some aspects of the 5q-- anomaly in ALL and its relation to previous experience with this karyotypic change are discussed.

摘要

本文介绍了一名4岁患急性淋巴细胞白血病（ALL）男孩的病例，其ALL可能继发于累及胸腔的淋巴瘤，该淋巴瘤经证实为T细胞型。白血病细胞存在5号染色体长臂缺失（5q--）异常，此前仅在难治性贫血和/或急性髓系白血病（AML）病例中有所描述。白血病细胞中的5q--异常总是伴有9号染色体短臂缺失（9p--）。通过显带技术显示，导致5q--染色体的中间缺失与先前在骨髓增殖性疾病中描述的类似。本文讨论了ALL中5q--异常的某些方面及其与这种核型变化既往经验的关系。