我们使用真皮替代物Nevelia®治疗严重烧伤患者的经验。

Our experience with dermal substitute Nevelia® in the treatment of severely burned patients.

作者信息

Yiğitbaş Hakan, Yavuz Erkan, Beken Özdemir Evrim, Onen Onder, Pençe Halime Hanim, Meriç Serhat, Çelik Atilla, Çelebi Fatih, Yasti Ahmet Cinar, Sapmaz Tansel, Zilan Aydın, Turan Mustafa

机构信息

Department of General Surgery, Health Sciences University Bağcılar Training and Research Hospital, İstanbul-Turkey.

Department of Biochemistry, Health Sciences University Faculty of Medicine, İstanbul-Turkey.

出版信息

Ulus Travma Acil Cerrahi Derg. 2019 Sep;25(5):520-526. doi: 10.14744/tjtes.2019.24358.

DOI:10.14744/tjtes.2019.24358

PMID:31475321

Abstract

BACKGROUND

This research aims to retrospectively evaluate the effectiveness and safety of dermal substitute (DS), Nevelia®, for the treatment of severely burned patients.

METHODS

Twenty severely burned patients were enrolled in this study between May 2017 and May 2018. After escharotomy of the wound, the treatment protocol was applied following a two-step procedure -DS implantation followed by split-thickness skin graft (STSG) application. Need for surgery, complications, hospitalisation duration and overall survival were analysed.

RESULTS

Mean age was 40.1±4 (18-86) years old; female/male: 5/15. Mean burn surface area was 50.1%±2 (25-96). Two patients died under hospital treatment due to the severity of their burn trauma and comorbidities. For the rest of the cases, STSG was performed after Nevelia® at mean 21.2 days. No complications due to Nevelia® were detected. The patients were discharged with a mean total recovery of 55.2±4 days.

CONCLUSION

This study showed that Nevelia® can be used safely and effectively in severely burned patients with low complication rates and short hospital stay.

摘要

背景

本研究旨在回顾性评估真皮替代物Nevelia®治疗重度烧伤患者的有效性和安全性。

方法

2017年5月至2018年5月期间，20例重度烧伤患者纳入本研究。伤口进行焦痂切开术后，按照两步程序应用治疗方案——先植入Nevelia®，然后进行自体中厚皮片移植（STSG）。分析手术需求、并发症、住院时间和总体生存率。

结果

平均年龄为40.1±4（18 - 86）岁；女性/男性为5/15。平均烧伤面积为50.1%±2（25 - 96）。两名患者因烧伤创伤严重和合并症在住院治疗期间死亡。其余病例在植入Nevelia®后平均21.2天进行了自体中厚皮片移植。未检测到因Nevelia®引起的并发症。患者出院时平均总康复时间为55.2±4天。