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真皮替代物在早期切除和后续皮肤自体移植后急性功能/活动解剖部位深度烧伤中的应用:真皮替代物可预防功能受限。

The Use of Dermal Substitute in Deep Burns of Functional/Mobile Anatomic Areas at Acute Phase After Early Excision and Subsequent Skin Autografting: Dermal Substitute Prevents Functional Limitations.

机构信息

Burn Center, Department of General Surgery, Adana City Training and Research Hospital, Turkey.

Department of General Surgery, Adana City Training and Research Hospital, Adana, Turkey.

出版信息

J Burn Care Res. 2020 Sep 23;41(5):1079-1083. doi: 10.1093/jbcr/iraa047.

Abstract

We aimed to evaluate the results of dermal substitute implantation after early excision in the acute phase of major burn cases within the scope of efforts to reduce contractions and scar formation in functional anatomic areas (face, neck, axilla, elbow, popliteal). Twelve patients with major burn who were treated in the burn center between September 2017 and September 2018 were included in the study. In these patients, Nevelia® dermal substitute was implanted into 24 functional areas with deep partial or full-thickness burns after surgical debridement of the wound. Autologous split-thickness skin graft was applied to these areas after 14 to 21 days. The patients were followed for 4 to 14 months (mean 6 months). Postoperative scar formation was assessed by the Vancouver Scar Scale at the end of the follow-up period. A simple qualitative staging system was used for aesthetic and functional evaluation. The time from burn injury to dermal substitute implantation was 3 to 21 days. Skin graft take was complete in 22 of 24 regions and partial in one of them, while graft loss developed in one region. In the implantation sites, the Vancouver Scar Scale ranged from 1 to 7. The aesthetic and functional evaluation showed excellent/good results in 21 of 24 anatomic regions, moderate results in 2 regions, and poor results in 1 region. The use of dermal substitute in deep burns of functional/mobile anatomic areas at the acute phase after early excision and subsequent skin autografting has opened a new alternative area in the burn surgery arena to prevent contractures and functional limitations.

摘要

我们旨在评估在急性大面积烧伤病例中,早期切除后皮替代物植入的效果,以期减少功能解剖区域(面部、颈部、腋窝、肘部、腘窝)的挛缩和瘢痕形成。2017 年 9 月至 2018 年 9 月期间,在烧伤中心接受治疗的 12 名大面积烧伤患者纳入本研究。在这些患者中,在对伤口进行手术清创后,将 Nevelia®真皮替代物植入 24 个存在深部分或全层烧伤的功能区域。14 至 21 天后,将自体刃厚皮片移植到这些区域。对这些患者进行了 4 至 14 个月(平均 6 个月)的随访。在随访期末,使用温哥华瘢痕量表评估术后瘢痕形成情况。采用简单的定性分期系统进行美学和功能评估。从烧伤到皮替代物植入的时间为 3 至 21 天。24 个区域中有 22 个的皮片完全存活,1 个部分存活,1 个区域出现皮片丢失。在植入部位,温哥华瘢痕量表评分为 1 至 7 分。在 24 个解剖区域中,21 个区域的美学和功能评估结果为优/良,2 个区域为中,1 个区域为差。在早期切除后急性阶段,在功能/活动解剖区域的深烧伤中使用真皮替代物,并随后进行自体皮片移植,为烧伤手术领域预防挛缩和功能限制开辟了一个新的选择领域。

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