External quality Control for Assays and Tests (ECAT) Foundation, Voorschoten, The Netherlands.
Br J Haematol. 2020 Feb;188(3):460-464. doi: 10.1111/bjh.16179. Epub 2019 Sep 2.
There is limited information regarding the performance of tests for direct oral anticoagulants (DOACs). To generate more knowledge, the accuracy of DOAC tests were evaluated using external quality assessment data from multiple years. This data demonstrated a good correlation for the tests with a small overall interlaboratory variability (10% for dabigatran, rivaroxaban and apixaban and 12% for edoxaban). The greatest differences between the various reagents were observed for rivaroxaban, especially for concentrations below 100 ng/ml. In conclusion, the results show overall reliable DOAC levels with some differences between reagent groups. Important finding: clinical decision criteria could be affected by the choice of reagent.
关于直接口服抗凝剂（DOACs）检测的性能，相关信息有限。为了获取更多知识，我们使用多年的外部质量评估数据来评估 DOAC 检测的准确性。该数据表明，这些检测的相关性良好，总体实验室间变异性较小（达比加群、利伐沙班和阿哌沙班为 10%，依度沙班为 12%）。对于利伐沙班，尤其是在浓度低于 100ng/ml 时，各种试剂之间的差异最大。总之，结果显示 DOAC 水平总体可靠，但试剂组之间存在一些差异。重要发现：临床决策标准可能会受到试剂选择的影响。
