Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Geriatr Gerontol Int. 2019 Oct;19(10):1010-1016. doi: 10.1111/ggi.13761. Epub 2019 Sep 1.
Nocturia is a common phenomenon in older individuals, and is associated with poor quality of life. Nocturia is a multifactorial disorder, wherein the frailty of skeletal muscles, particularly muscle weakness in the lower trunk and hip regions, might be a risk factor in women. We analyzed a dataset of the general Japanese population to clarify the hypothesis.
Study participants included 1207 older women (mean age 67.4 ± 5.2 years). The frequency of nocturnal urination was assessed using a sleep diary for 1 week, and associations with lower muscle strength, skeletal muscle index, sarcopenia and physical performance (one-leg standing time and Timed Up and Go test) were investigated.
The frequency of nocturnal urination more than one voiding per night was 28.1%; this frequency was inversely associated with hip abduction strength quartiles (Q1: 37.0, Q2: 30.5, Q3: 25.1 and Q4: 19.9%, P < 0.001). When a sleep diary-based nocturnal urination frequency >1.5 times/night (corresponding to a ≥2 times/night frequency obtained by questionnaire) was considered as nocturia, logistic regression analysis adjusted for major covariates identified hip abduction strength as an independent inverse determinant of nocturia (odds ratio 0.75, 95% CI 0.52-0.90, P = 0.002). In contrast, no significant association was observed with knee extension (P = 0.322) and hip flexion (P = 0.603) strengths. Physical performance, skeletal muscle index and sarcopenia did not show significant associations with nocturia.
Weak hip abduction strength might be a factor associated with nocturnal urination frequency in older women. Geriatr Gerontol Int 2019; 19: 1010-1016.
夜尿症是老年人的一种常见现象，与生活质量较差有关。夜尿症是一种多因素疾病，骨骼肌肉，尤其是下躯干和臀部的肌肉无力，可能是女性的一个危险因素。我们分析了一般日本人群的数据组以验证该假说。
研究对象包括 1207 名老年女性（平均年龄 67.4±5.2 岁）。使用睡眠日记评估 1 周内夜间排尿频率，并调查其与下肢肌肉力量、骨骼肌指数、肌肉减少症和身体机能（单腿站立时间和计时起立行走测试）的相关性。
每晚夜间排尿次数多于一次的频率为 28.1%；该频率与髋关节外展力量四分位（Q1：37.0，Q2：30.5，Q3：25.1，Q4：19.9%，P<0.001）呈负相关。当基于睡眠日记的夜间排尿频率>1.5 次/夜（相当于问卷获得的>2 次/夜频率）被认为是夜尿症时，经主要混杂因素校正的 logistic 回归分析确定髋关节外展力量是夜尿症的独立负相关因素（比值比 0.75，95%置信区间 0.52-0.90，P=0.002）。相反，与膝关节伸展力量（P=0.322）和髋关节屈曲力量（P=0.603）均无显著相关性。身体机能、骨骼肌指数和肌肉减少症与夜尿症均无显著相关性。
髋关节外展力量较弱可能是老年女性夜间排尿频率的一个相关因素。
