Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Geriatr Gerontol Int. 2019 Oct;19(10):1017-1022. doi: 10.1111/ggi.13762. Epub 2019 Sep 15.
Advanced glycation end-products are important factors in muscle function and physical performance among older adults. However, the association between sarcopenia and urinary carboxymethyl-lysine (uCML) levels remains unclear. The present study aimed to investigate the relationship among uCML levels, skeletal muscle mass, physical performance and sarcopenia among community-dwelling older adults.
This work was a community-based cross-sectional study. The participants were recruited from the Taichung Community Health Study-Elderly and were followed up until 2017. A total of 104 participants underwent dual-energy X-ray absorptiometry examination, physical performance tests and measurement of uCML levels. After the natural log transformation of the uCML levels, Pearson's correlation coefficient and a general linear model were used for statistical analysis.
The mean uCML levels of older men and women were 1.34 μg/mg and 1.63 μg/mg creatinine, respectively. After multivariate adjustment, grip strength among older women significantly decreased as uCML levels increased. Participants with uCML levels and Timed Up and Go test values higher than the median had a 13.76-fold risk of acquiring sarcopenia compared with those whose corresponding variables were lower than the median after adjusting for age, sex, body fat percentage, and serum creatinine and blood urea nitrogen levels.
uCML levels were negatively associated with grip strength among older women. The joint association of uCML and Timed Up and Go test values was correlated with the risk of acquiring sarcopenia among older adults. This finding suggests that uCML levels can be used as a biomarker for screening sarcopenia and as a strategy for treating sarcopenia. Geriatr Gerontol Int 2019; 19: 1017-1022.
糖基化终产物是老年人肌肉功能和身体表现的重要因素。然而，肌少症与尿羧甲基赖氨酸（uCML）水平之间的关系尚不清楚。本研究旨在探讨社区老年人 uCML 水平、骨骼肌量、身体表现与肌少症之间的关系。
这是一项基于社区的横断面研究。参与者从台中市社区健康研究-老年人中招募，并随访至 2017 年。共有 104 名参与者接受了双能 X 射线吸收法检查、身体表现测试和 uCML 水平测量。对 uCML 水平进行自然对数转换后，采用 Pearson 相关系数和一般线性模型进行统计分析。
男性和女性老年人的 uCML 水平平均值分别为 1.34μg/mg 和 1.63μg/mg 肌酐。经过多变量调整后，女性老年人的握力随着 uCML 水平的升高而显著下降。与 uCML 水平和计时起立行走测试值低于中位数的参与者相比，uCML 水平和计时起立行走测试值高于中位数的参与者在调整年龄、性别、体脂百分比以及血清肌酐和血尿素氮水平后发生肌少症的风险增加了 13.76 倍。
uCML 水平与女性老年人的握力呈负相关。uCML 和计时起立行走测试值的联合关联与老年人发生肌少症的风险相关。这一发现表明，uCML 水平可用作肌少症筛查的生物标志物，并作为治疗肌少症的策略。
