Department of Bioengineering, University of Information Science and Technology, Partizahska, Ohrid, Republic of Macedonia.
Curr Pharm Des. 2019;25(31):3367-3377. doi: 10.2174/1381612825666190902162105.
Presently, malaria is one of the most prevalent and deadly infectious disease across Africa, Asia, and America that has now started to spread in Europe. Despite large research being carried out in the field, still, there is a lack of efficient anti-malarial therapeutics. In this paper, we highlight the increasing efforts that are urgently needed towards the development and discovery of potential antimalarial drugs, which must be safe and affordable. The new drugs thus mentioned are also able to counter the spread of malaria parasites that have been resistant to the existing agents.
The main objective of the review is to highlight the recent development in the use of system biologybased approaches towards the design and discovery of novel anti-malarial inhibitors.
A huge literature survey was performed to gain advance knowledge about the global persistence of malaria, its available treatment and shortcomings of the available inhibitors. Literature search and depth analysis were also done to gain insight into the use of system biology in drug discovery and how this approach could be utilized towards the development of the novel anti-malarial drug.
The system-based analysis has made easy to understand large scale sequencing data, find candidate genes expression during malaria disease progression further design of drug molecules those are complementary of the target proteins in term of shape and configuration.
The review article focused on the recent computational advances in new generation sequencing, molecular modeling, and docking related to malaria disease and utilization of the modern system and network biology approach to antimalarial potential drug discovery and development.
目前，疟疾是非洲、亚洲和美洲最流行和最致命的传染病之一，现在已经开始在欧洲传播。尽管在该领域进行了大量研究，但仍然缺乏有效的抗疟疗法。在本文中，我们强调了迫切需要在开发和发现潜在抗疟药物方面做出更多努力，这些药物必须安全且价格实惠。新提到的药物还能够对抗已经对现有药物产生抗药性的疟原虫的传播。
本文的主要目的是强调基于系统生物学的方法在设计和发现新型抗疟抑制剂方面的最新进展。
进行了大量的文献调查，以了解疟疾在全球的持续存在、可用的治疗方法以及现有抑制剂的不足之处。还进行了文献搜索和深度分析，以了解系统生物学在药物发现中的应用，以及如何利用这种方法开发新型抗疟药物。
基于系统的分析使得理解大规模测序数据变得更加容易，发现疟疾疾病进展过程中候选基因的表达，进一步设计与靶蛋白在形状和构象上互补的药物分子。
本文主要关注与疟疾相关的新一代测序、分子建模和对接方面的最新计算进展，以及利用现代系统和网络生物学方法对抗疟药物的潜在发现和开发。
