Guan Jian, Li Yao, Ding Luo-Bin, Liu Guang-Yuan, Zheng Xiao-Fei, Xue Wei, Wang Hua-Jun
Department of Orthopedic Surgery, Third Hospital of Shi Jiazhuang, Shi Jiazhuang, Hebei Province, China.
Department of Orthopedic Surgery and Sports Medicine Center, First Affiliated Hospital of Jinan University, GuangZhou, Guang Dong Province, China.
J Musculoskelet Neuronal Interact. 2019 Sep 1;19(3):326-332.
The current study was performed to examine serum and synovial fluid (SF) CCL20 levels and their correlations with disease severity in primary knee osteoarthritis patients.
A total of 99 patients diagnosed with primary knee OA were enrolled in the study, and 95 healthy individuals receiving regular medical examination were recruited as controls. Serum and SF CCL20 concentrations were determined using an enzyme-linked immunosorbent assay. The radiographic severity of OA was assessed by the Kellgren-Lawrence (K-L) classification system. The Lequesne algofunctional index and a visual analogue scale (VAS) were used to evaluate the clinical severity of knee OA in patients.
The serum CCL20 levels were not significantly different between patients with knee OA and controls. Patients with a K-L grade of 4 had significantly higher SF CCL20 levels than those with K-L grades of 2 and 3. Knee OA patients with a K-L grade of 3 showed significantly higher levels of CCL20 in SF than those with a K-L grade of 2. In addition, SF CCL20 levels were significantly related to the Lequesne algofunctional index and VAS score.
These findings suggest that local CCL20 levels may reflect the disease severity of knee OA.
本研究旨在检测原发性膝骨关节炎患者血清及滑液（SF）中CCL20水平，并探讨其与疾病严重程度的相关性。
本研究共纳入99例诊断为原发性膝骨关节炎的患者，并招募95例接受定期体检的健康个体作为对照。采用酶联免疫吸附测定法测定血清和SF中CCL20的浓度。采用Kellgren-Lawrence（K-L）分类系统评估骨关节炎的影像学严重程度。采用Lequesne功能指数和视觉模拟量表（VAS）评估患者膝骨关节炎的临床严重程度。
膝骨关节炎患者与对照组血清CCL20水平无显著差异。K-L分级为4级的患者SF中CCL20水平显著高于K-L分级为2级和3级的患者。K-L分级为3级的膝骨关节炎患者SF中CCL20水平显著高于K-L分级为2级的患者。此外，SF中CCL20水平与Lequesne功能指数和VAS评分显著相关。
这些发现表明，局部CCL20水平可能反映膝骨关节炎的疾病严重程度。
