Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Chem Commun (Camb). 2019 Sep 17;55(75):11287-11290. doi: 10.1039/c9cc05310g.
A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5'-guanosine monophosphate (5'-GMP) produced both PtIV and PtII 5'-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals - particularly hydroxyl radicals - was significantly reduced in the presence of 5'-GMP.
通过 PtIV 叠氮化物配合物（1）与 Sondheimer 二炔（2）之间的应变促进的双点击反应（SPDC），合成了一种新型的 PtIV 三唑叠氮配合物[3]-[N1，N3]。在 5'-单磷酸鸟苷（5'-GMP）的存在下，用可见光（452nm）光激活[3]-[N1，N3]，生成了 PtIV 和 PtII 5'-GMP 物种；电子顺磁共振（EPR）光谱证实了叠氮基和羟基自由基的生成。在 5'-GMP 的存在下，光生自由基（特别是羟基自由基）的捕获显著减少。
