Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
Org Biomol Chem. 2010 Sep 21;8(18):4051-5. doi: 10.1039/c0ob00003e. Epub 2010 Jul 26.
The strain-promoted "double-click" (SPDC) reaction using Sondheimer diyne, a novel convergent method conjugating three molecules spontaneously, has enabled us to readily modify an azido-biomolecule with a small reporter azido-molecule.
利用 Sondheimer 二炔的应变促进“双击”（SPDC）反应，这是一种新的会聚方法，可以自发地连接三个分子，使我们能够轻松地用一个小报告分子叠氮化物修饰一个叠氮生物分子。
