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应变促进的叠氮生物分子化学修饰的双击反应。

Strain-promoted double-click reaction for chemical modification of azido-biomolecules.

机构信息

Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.

出版信息

Org Biomol Chem. 2010 Sep 21;8(18):4051-5. doi: 10.1039/c0ob00003e. Epub 2010 Jul 26.

DOI:10.1039/c0ob00003e
PMID:20657923
Abstract

The strain-promoted "double-click" (SPDC) reaction using Sondheimer diyne, a novel convergent method conjugating three molecules spontaneously, has enabled us to readily modify an azido-biomolecule with a small reporter azido-molecule.

摘要

利用 Sondheimer 二炔的应变促进“双击”（SPDC）反应，这是一种新的会聚方法，可以自发地连接三个分子，使我们能够轻松地用一个小报告分子叠氮化物修饰一个叠氮生物分子。

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Strain-promoted double-click reaction for chemical modification of azido-biomolecules.

Org Biomol Chem. 2010-7-26

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