呼吸困难是帕金森病的一种特异性症状。
Dyspnea Is a Specific Symptom in Parkinson's Disease.
机构信息
Department of Neurology, Expert Center for Parkinson's Disease, INSERM UMRS_1171, Lille University Medical Center, LICEND COEN center, Lille, France.
CHU Lille, Lung Function Department, Univ Lille, INSERM 1019, CNRS UMR 8204, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France.
出版信息
J Parkinsons Dis. 2019;9(4):785-791. doi: 10.3233/JPD-191713.
BACKGROUND
Dyspnea is a multidimensional sensation that is reported in Parkinson's disease (PD). The multidimensional dyspnea profile (MDP) questionnaire can help to distinguish the perceptive dimension and the emotion response.
OBJECTIVE
The aim was to assess the clinical features associated with dyspnea using the MDP questionnaire in order to determine which aspects of the symptom was linked with anxiety, depression or motor severity of the disease.
METHODS
Non-demented patients were asked whether they experienced shortness of breath in the last month. In case of positive answer, dyspnea was assessed by the MDP. MDS-UPDRS, global cognitive performance, non-motor symptoms and quality of life were assessed.
RESULTS
60/163 patients were dyspneic since 4.6±2.4 years. The most frequent best sensory quality (SQ) described were: hyperpnoea (35%), physical breathing effort (25%) and air hunger (20%). Hyperpnoea and air hunger had the highest SQ intensity. Anxiety had the highest intensity in the emotional domain.
CONCLUSION
Dyspnea is a frequent symptom in PD, with specific presentations and two main aspects: one related with anxiety and another with ventilation control impairment.
背景
呼吸困难是帕金森病（PD）患者的一种多维感觉。多维呼吸困难量表（MDP）问卷可帮助区分感知维度和情绪反应。
目的
本研究旨在使用 MDP 问卷评估与呼吸困难相关的临床特征，以确定症状的哪些方面与焦虑、抑郁或疾病的运动严重程度有关。
方法
询问非痴呆患者在过去一个月是否有呼吸急促。如果回答为是，则使用 MDP 评估呼吸困难。评估 MDS-UPDRS、整体认知表现、非运动症状和生活质量。
结果
60/163 例患者呼吸困难持续时间为 4.6±2.4 年。最常见的最佳感觉质量（SQ）描述为：过度通气（35%）、体力呼吸费力（25%）和空气饥饿（20%）。过度通气和空气饥饿的 SQ 强度最高。焦虑在情绪领域的强度最高。
结论
呼吸困难是 PD 的常见症状，具有特定的表现和两个主要方面：一个与焦虑有关，另一个与通气控制障碍有关。
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