J Phys Act Health. 2019 Oct 1;16(10):916-924. doi: 10.1123/jpah.2018-0568. Epub 2019 Sep 1.
This study sought to determine the impact of an acute prior bout of high-intensity interval aerobic exercise on attenuating the vascular dysfunction associated with a prolonged sedentary bout.
Ten young (24 ± 1 y) healthy males completed two 3-hour sessions of prolonged sitting with (SIT-EX) and without (SIT) a high-intensity interval aerobic exercise session performed immediately prior. Prior to and 3 hours into the sitting bout, leg vascular function was assessed with the passive leg movement technique, and blood samples were obtained from the lower limb to evaluate changes in oxidative stress (malondialdehyde and superoxide dismutase) and inflammation (interleukin-6).
No presitting differences in leg vascular function (assessed via passive leg movement technique-induced hyperemia) were revealed between conditions. After 3 hours of prolonged sitting, leg vascular function was significantly reduced in the SIT condition, but unchanged in the SIT-EX. Lower limb blood samples revealed no alterations in oxidative stress, antioxidant capacity, or inflammation in either condition.
This study revealed that lower limb vascular dysfunction was significantly attenuated by an acute presitting bout of high-intensity interval aerobic exercise. Further analysis of lower limb blood samples revealed no changes in circulating oxidative stress or inflammation in either condition.
本研究旨在确定急性高强度间歇有氧运动对缓解长时间久坐引起的血管功能障碍的影响。
10 名年轻（24±1 岁）健康男性完成了两次 3 小时的久坐实验，其中一次（SIT-EX）在久坐前进行了高强度间歇有氧运动，另一次（SIT）则没有。在久坐开始前和 3 小时，使用被动腿部运动技术评估腿部血管功能，并从下肢采集血液样本，以评估氧化应激（丙二醛和超氧化物歧化酶）和炎症（白细胞介素-6）的变化。
两种条件下，被动腿部运动技术诱导的充血引起的腿部血管功能在久坐前均无差异。3 小时久坐后，SIT 条件下腿部血管功能明显降低，但 SIT-EX 条件下则没有变化。两种条件下，下肢血液样本均未显示氧化应激、抗氧化能力或炎症的变化。
本研究表明，急性高强度间歇有氧运动可以显著减轻下肢血管功能障碍。进一步分析下肢血液样本显示，两种条件下循环氧化应激或炎症均无变化。
