Wang Yahai, Luo Donglin, Jiang Haichao, Song Yu, Wang Zhiqiang, Shao Lin, Liu Yuxiao
College of Arts and Physical Education, Nanchang Normal College of Applied Technology, Nanchang, 330108, Jiangxi Province, China.
Faculty of Health Service, Naval Medical University, Shanghai, 200433, China.
Open Life Sci. 2023 Aug 8;18(1):20220668. doi: 10.1515/biol-2022-0668. eCollection 2023.
This meta-analysis investigated the effect of physical exercise (PE) on the levels of oxidative biomarkers in randomized controlled trials (RCTs) involving healthy subjects. We searched five databases for articles until May 1, 2023. A random-effect meta-analysis, subgroup analysis, meta-regressions as well as trim and fill method were conducted using STATA 11.0, involving ten articles. According to the results of the meta-analysis, PE had no significant effect on superoxide dismutase (SOD), glutathione peroxidase, and catalase levels. PE induced significant increase in total antioxidant status (standardized mean difference [SMD] 1.53, 95% CI 0.73-2.32), and PE could significantly reduce the level of malondialdehyde (MDA) (SMD -1.11, 95% CI -2.15 to -0.06). Sensitivity analyses and subgroup analyses showed that male participants, body mass index (BMI) <25, exercise duration between 1 and 12 weeks, resistance exercise or multicomponent exercise, and exercise of low or moderate intensity were associated with a significant PE-induced decrease in MDA concentrations. Meta-regression analysis identified the age of the participants as a confounder of the effect of PE on SOD levels. The older age of the subjects was associated in a gradient fashion with incident SOD levels. Further RCTs are required to investigate the optimal PE protocol for people of different ages and BMI as well as the effect of PE on oxidative stress.
这项荟萃分析在涉及健康受试者的随机对照试验（RCT）中研究了体育锻炼（PE）对氧化生物标志物水平的影响。我们在五个数据库中检索文章直至2023年5月1日。使用STATA 11.0进行了随机效应荟萃分析、亚组分析、元回归以及修剪和填充法，共纳入十篇文章。根据荟萃分析结果，体育锻炼对超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶和过氧化氢酶水平无显著影响。体育锻炼使总抗氧化状态显著增加（标准化均值差[SMD] 1.53，95%可信区间0.73 - 2.32），且体育锻炼可显著降低丙二醛（MDA）水平（SMD -1.11，95%可信区间 -2.15至 -0.06）。敏感性分析和亚组分析表明，男性参与者、体重指数（BMI）<25、锻炼持续时间在1至12周之间、抗阻运动或多组分运动以及低强度或中等强度运动与体育锻炼引起的MDA浓度显著降低相关。元回归分析确定参与者年龄是体育锻炼对SOD水平影响的一个混杂因素。受试者年龄越大，SOD水平呈梯度相关。需要进一步的随机对照试验来研究针对不同年龄和BMI人群的最佳体育锻炼方案以及体育锻炼对氧化应激的影响。
