From the Department of Pediatrics, (X.C., Y.W.) Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Hypertension. 2019 Oct;74(4):733-739. doi: 10.1161/HYPERTENSIONAHA.119.13458. Epub 2019 Sep 3.
Pulmonary hypertension (PH) is a severe disease with multiple etiologies. In addition to genetics, recent studies have revealed the epigenetic modulation in the initiation and progression of PH. In this review, we summarize the epigenetic mechanisms in the pathogenesis of PH, specifically, DNA methylation, histone modifications, and microRNAs. We further emphasize the diagnostic and therapeutic potential of these epigenetic hallmarks in PH. Finally, we highlight the developmental reprogramming in adult-onset PH because of adverse perinatal exposures such as intrauterine growth restriction and extrauterine growth restriction. Therefore, epigenetic modifications provide promise for the therapy and prevention of PH.
肺动脉高压（PH）是一种病因多样的严重疾病。除了遗传因素外，最近的研究还揭示了表观遗传调控在 PH 的发生和发展中的作用。在这篇综述中，我们总结了 PH 发病机制中的表观遗传机制，特别是 DNA 甲基化、组蛋白修饰和 microRNAs。我们进一步强调了这些表观遗传特征在 PH 中的诊断和治疗潜力。最后，我们强调了由于宫内生长受限和宫外生长受限等围产期不良暴露导致的成人发病 PH 中的发育重编程。因此，表观遗传修饰为 PH 的治疗和预防提供了希望。
