Winkler H H, Wood D O
Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile 36688.
Biochimie. 1988 Aug;70(8):977-86. doi: 10.1016/0300-9084(88)90262-3.
The relationship between DNA base composition and codon bias in very AT-rich bacteria was analyzed. Five clostridial genes, five mycoplasmal genes and three rickettsial genes constituted the data base. In the genes of these three organisms, the rule for codon bias was very simple: use U or A in the first and third positions of the codon when possible. This was contrasted with the bias found in Bacillus subtilis and Escherichia coli. The rule for Bacillus subtilis was equally straightforward: use all codons without bias. Only in E. coli, amongst the species examined, did the codon bias appear to be a complicated codon 'choice'.
分析了富含AT的细菌中DNA碱基组成与密码子偏好之间的关系。五个梭菌属基因、五个支原体属基因和三个立克次氏体属基因构成了数据库。在这三种生物的基因中，密码子偏好规则非常简单：尽可能在密码子的第一位和第三位使用U或A。这与枯草芽孢杆菌和大肠杆菌中发现的偏好形成对比。枯草芽孢杆菌的规则同样简单直接：无偏好地使用所有密码子。在所研究的物种中，只有大肠杆菌的密码子偏好似乎是一种复杂的密码子“选择”。
