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不典型肺类癌的不典型诊断。

Atypical diagnosis for typical lung carcinoid.

机构信息

Respiratory Diseases Unit, Azienda Unità Sanitaria Locale - IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Viale Risorgimento 80, 42123, Reggio Emilia, Italy.

Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, Modena, Italy.

出版信息

BMC Pulm Med. 2019 Sep 2;19(1):168. doi: 10.1186/s12890-019-0929-0.

Abstract

BACKGROUND

The diagnosis of lung typical carcinoid tumors results challenging when limited size and unfavorable sampling location is associated. It has been reported that bronchoscopy with endobronchial ultrasound (EBUS) significantly increases the diagnostic yield of peripheral nodules smaller than 2 cm.

CASE PRESENTATION

A 70-year-old Caucasian male complained of persistent fever and cough despite several antibiotic courses and steroid treatment. Chest radiology revealed the presence of a small single nodular opacity in the left upper lobe, whose standardized maximum uptake value (SUV) at fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) was significantly high (4.5). The patient underwent bronchial endoscopy but any appreciable sign of endobronchial or intramural involvement was detected. Only radial ultrasound-guided bronchoscopy (R-EBUS) allowed transbronchial sampling whose pathological analysis revealed a typical carcinoid tumor. The patients underwent surgical lobectomy and clinic-radiological follow was started.

CONCLUSIONS

With this case we aim at stressing the importance of ultrasound in the diagnostic process of lung small peripheral carcinoid, especially if they present without mucosal or sub mucosal involvement.

摘要

背景

当肿瘤体积较小且采样位置不佳时,肺典型类癌肿瘤的诊断颇具挑战性。有报道称,支气管内超声(EBUS)支气管镜检查显著提高了直径小于 2cm 的外周结节的诊断率。

病例介绍

一名 70 岁的白人男性因持续发热和咳嗽而就诊,尽管已接受了多次抗生素治疗和类固醇治疗,但症状仍未缓解。胸部放射学检查显示左肺上叶存在一个小结节状不透明影,其氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描(FDG PET/CT)的标准化最大摄取值(SUV)显著升高(4.5)。患者接受了支气管内镜检查,但未发现任何明显的支气管内或壁内受累迹象。只有径向超声引导支气管镜(R-EBUS)能够进行经支气管取样,其病理分析显示为典型类癌肿瘤。患者随后接受了肺叶切除术,开始了临床和影像学随访。

结论

通过本例,我们旨在强调超声在肺部小周边型类癌的诊断过程中的重要性,尤其是当肿瘤无黏膜或黏膜下受累时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9292/6719370/f931a898c8ca/12890_2019_929_Fig1_HTML.jpg

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