Radboud university medical center, Dept. of Obstetrics and Gynaecology, 791, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.
Integraal kankercentrum Nederland, PO Box 19079, 3501, DB, Utrecht, the Netherlands.
Gynecol Oncol. 2019 Nov;155(2):213-219. doi: 10.1016/j.ygyno.2019.08.018. Epub 2019 Aug 30.
Optimizing the counselling of women ≤40years with epithelial ovarian cancer (EOC) by investigating the role of young age and tumour characteristics on overall survival (OS).
A retrospective population-based study was done using data of EOC patients diagnosed between 1990 and 2014 registered in the Netherlands Cancer Registry. Descriptive statistics were performed to analyse clinical and tumour characteristics. Five- and 10-year OS rates were calculated using Kaplan Meier curves. To determine prognostic factors, univariable and multivariable survival analyses were performed.
1407 women ≤40years and 29,022 women >40years old were included. OS was higher for the younger women compared to older group (5-year survival of 65.6% vs. 32.7%, 10-year survival of 57.5% vs. 22.5%, respectively). The younger women had more often a mucinous (36.4%), well-differentiated (31.8%) tumour in early stage of disease (49.9%). Serous tumours (43.0%), high-grade (36.0%) and stage III (47.1%) were most frequently found in the older women. Histology, grade, stage, incidence year, and age group are independent prognostic factors for survival. OS of the young women for several combinations of tumour characteristics were calculated.
Age is an independent prognostic factor for OS in EOC patients. Counselling on prognosis could be more individualised in young EOC patients using the tumour characteristics histology, stage and grade.
通过研究年龄和肿瘤特征对总生存期（OS）的影响，优化≤40 岁上皮性卵巢癌（EOC）患者的咨询。
本研究使用荷兰癌症登记处 1990 年至 2014 年间诊断的 EOC 患者的数据进行了回顾性基于人群的研究。进行了描述性统计分析以分析临床和肿瘤特征。使用 Kaplan-Meier 曲线计算 5 年和 10 年 OS 率。为了确定预后因素，进行了单变量和多变量生存分析。
纳入了 1407 名≤40 岁和 29022 名>40 岁的女性。年轻女性的 OS 高于年长女性（5 年生存率分别为 65.6%和 32.7%，10 年生存率分别为 57.5%和 22.5%）。年轻女性的肿瘤更常为黏液性（36.4%）、分化良好（31.8%）、早期疾病（49.9%）。年长女性更常发现浆液性肿瘤（43.0%）、高级别（36.0%）和 III 期（47.1%）。组织学、分级、分期、发病年份和年龄组是生存的独立预后因素。计算了年轻女性几种肿瘤特征组合的 OS。
年龄是 EOC 患者 OS 的独立预后因素。对于年轻的 EOC 患者，使用肿瘤特征组织学、分期和分级，可以更个体化地进行预后咨询。
