卵巢癌保留生育功能手术的实际意义：生殖结局

Real Implication of Fertility-Sparing Surgery for Ovarian Cancer: Reproductive Outcomes.

作者信息

Heras Marta, Alonso-Espias Maria, Arencibia Octavio, Minig Lucas, Marti Lola, Diestro Maria Dolores, Cespedes Juan, Niguez Isabel, Gil-Ibañez Blanca, Diaz-Feijoo Berta, Llueca Antoni, Rosado Claudia, Iacoponi Sara, Lopez de la Manzanara Carlos, Morales Sara, Fernandez-Galguera Maria Jose, Cano Ana, Gorostidi Mikel, Zapardiel Ignacio

机构信息

Gynecology Department, Hospital Universitario Santa Cristina, 28009 Madrid, Spain.

Gynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, Spain.

出版信息

Diagnostics (Basel). 2024 Jul 3;14(13):1424. doi: 10.3390/diagnostics14131424.

DOI:10.3390/diagnostics14131424

PMID:39001314

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11241223/

Abstract

BACKGROUND

to prove the effectivity of fertility-sparing procedures in early-stage ovarian cancer by assessing pregnancy rates and obstetrical outcomes.

METHODS

we performed a retrospective multicenter study among 55 Spanish hospitals, collecting patients from 18 to 40 years old with diagnosis of early-stage ovarian cancer, epithelial (EOC) or non-epithelial (non-EOC), from January 2010 to December 2019. Data on the use of assisted reproductive techniques, pregnancy attempts and obstetrical outcomes were collected.

RESULTS

a total of 150 patients met inclusion criteria, 70 (46.6%) EOC and 80 (53.4%) non-EOC. Pregnancy attempts were reported in 51 (34%) patients, with 42 (28%) patients carrying the pregnancy to term. Among them, 30 (71.4%) underwent surgery alone and 12 (28.6%) had additional postoperative chemotherapy. A total of 32 (76.1% patients) had spontaneous pregnancies and 10 (23.9%) required in vitro fertilization. There was only one (2.4%) complication reported. Vaginal delivery was reported in twenty-nine (69%) patients and cesarean section in five (11.9%) patients.

CONCLUSIONS

fertility-sparing management for ovarian cancer seems to be an option with proven good pregnancy rates and low complications. The selection of patients must consider strict criteria in order to maintain a good prognosis.

摘要

背景

通过评估妊娠率和产科结局来证明保留生育功能手术在早期卵巢癌中的有效性。

方法

我们在55家西班牙医院进行了一项回顾性多中心研究，收集了2010年1月至2019年12月期间年龄在18至40岁、诊断为早期卵巢癌（上皮性卵巢癌[EOC]或非上皮性卵巢癌[非EOC]）的患者。收集了辅助生殖技术的使用、妊娠尝试和产科结局的数据。

结果

共有150例患者符合纳入标准，其中70例（46.6%）为EOC，80例（53.4%）为非EOC。51例（34%）患者报告有妊娠尝试，42例（28%）患者妊娠至足月。其中，30例（71.4%）仅接受了手术，12例（28.6%）术后接受了额外化疗。共有32例（76.1%的患者）自然受孕，10例（23.9%）需要体外受精。仅报告了1例（2.4%）并发症。29例（69%）患者经阴道分娩，5例（11.9%）患者行剖宫产。