O'Neill H J, Gordon S M, Krotoszynski B, Kavin H, Szidon J P
IIT Research Institute, Department of Chemistry, Chicago, Illinois 60616.
Biomed Chromatogr. 1987;2(2):66-70. doi: 10.1002/bmc.1130020206.
Expired air samples have been analyzed from three groups of human subjects (normal, liver dysfunction, lung cancer) and the baboon (Papio anubus). Of the several hundred compounds present, three compounds were of particular interest due to their structural relationship to the isoprenoid-type intermediates in the sterol pathway. These compounds were 1-methyl-4-(1-methyl-ethenyl)-cyclohexene, 6-methyl-5-hepten-2-one, and 6,10-dimethyl-5,9-undecadien-2-one. Hydroxyacetone was also found in all samples screened. The relationship of these compounds to the non-sterol pathway of mevalonate metabolism is discussed.
已对三组人类受试者（正常、肝功能不全、肺癌）和狒狒（东非狒狒）的呼出气体样本进行了分析。在所存在的数百种化合物中，有三种化合物因其与甾醇途径中类异戊二烯型中间体的结构关系而特别令人关注。这些化合物是1-甲基-4-（1-甲基乙烯基）环己烯、6-甲基-5-庚烯-2-酮和6,10-二甲基-5,9-十一碳二烯-2-酮。在所有筛查的样本中还发现了羟基丙酮。讨论了这些化合物与甲羟戊酸代谢的非甾醇途径的关系。
